Beyond the hippocampus and the SVZ: adult neurogenesis throughout the brain
Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …
mammalian brain into adulthood. Adult neurogenesis has been best described in the …
BDNF and synaptic plasticity, cognitive function, and dysfunction
B Lu, G Nagappan, Y Lu - Neurotrophic factors, 2014 - Springer
Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high
level of expression in the brain and its potent effects on synapses. It is now widely accepted …
level of expression in the brain and its potent effects on synapses. It is now widely accepted …
[HTML][HTML] Role of BDNF epigenetics in activity-dependent neuronal plasticity
NN Karpova - Neuropharmacology, 2014 - Elsevier
Brain-derived neurotrophic factor (BDNF) is a key mediator of the activity-dependent
processes in the brain that have a major impact on neuronal development and plasticity …
processes in the brain that have a major impact on neuronal development and plasticity …
Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis
Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of a
polyglutamine repeat within the HD gene product, huntingtin. Huntingtin, a large (347 kDa) …
polyglutamine repeat within the HD gene product, huntingtin. Huntingtin, a large (347 kDa) …
Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis
Huntington disease is a neurodegenerative disorder caused by a CAG repeat amplification
in the gene huntingtin (HTT) that is reflected by a polyglutamine expansion in the Htt protein …
in the gene huntingtin (HTT) that is reflected by a polyglutamine expansion in the Htt protein …
Tremendous fidelity of vitamin D3 in age-related neurological disorders
M Skv, SM Abraham, O Eshwari, K Golla… - Molecular …, 2024 - Springer
Vitamin D3 (VD) is a secosteroid hormone and shows a pleiotropic effect in brain-related
disorders where it regulates redox imbalance, inflammation, apoptosis, energy production …
disorders where it regulates redox imbalance, inflammation, apoptosis, energy production …
The role of CPEB family proteins in the nervous system function in the norm and pathology
Posttranscriptional gene regulation includes mRNA transport, localization, translation, and
regulation of mRNA stability. CPEB (c ytoplasmic p olyadenylation e lement b inding) family …
regulation of mRNA stability. CPEB (c ytoplasmic p olyadenylation e lement b inding) family …
Huntingtin is an RNA binding protein and participates in NEAT1-mediated paraspeckles
Huntingtin protein, mutated in Huntington's disease, is implicated in nucleic acid–mediated
processes, yet the evidence for direct huntingtin–nucleic acid interaction is limited. Here, we …
processes, yet the evidence for direct huntingtin–nucleic acid interaction is limited. Here, we …
The effects of huntingtin-lowering: what do we know so far?
WF Kaemmerer, RC Grondin - Degenerative neurological and …, 2019 - Taylor & Francis
Therapies targeting mutant huntingtin DNA, mRNA, and protein have a chance at becoming
the first disease-modifying treatments for Huntington's disease, a fatal inherited …
the first disease-modifying treatments for Huntington's disease, a fatal inherited …
Beyond good and evil: a putative continuum-sorting hypothesis for the functional role of proBDNF/BDNF-propeptide/mBDNF in antidepressant treatment
Depression and posttraumatic stress disorder are assumed to be maladaptive responses to
stress and antidepressants are thought to counteract such responses by increasing BDNF …
stress and antidepressants are thought to counteract such responses by increasing BDNF …