Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Lanthanide probes for bioresponsive imaging

MC Heffern, LM Matosziuk, TJ Meade - Chemical reviews, 2014 - ACS Publications
The chemistry of the less familiar elements is a fascinating topic especially for the inorganic
minded. The lanthanides, or rare earths, comprise the 5d block of the periodic table and …

Molecular magnetic resonance imaging with Gd (III)-based contrast agents: challenges and key advances

H Li, TJ Meade - Journal of the American Chemical Society, 2019 - ACS Publications
In an era of personalized medicine, the clinical community has become increasingly focused
on understanding diseases at the cellular and molecular levels. Magnetic resonance …

Nuts and bolts of chemical exchange saturation transfer MRI

G Liu, X Song, KWY Chan… - NMR in Biomedicine, 2013 - Wiley Online Library
Chemical exchange saturation transfer (CEST) has emerged as a novel MRI contrast
mechanism that is well suited for molecular imaging studies. This new mechanism can be …

Clinical imaging in regenerative medicine

AV Naumova, M Modo, A Moore, CE Murry… - Nature …, 2014 - nature.com
In regenerative medicine, clinical imaging is indispensable for characterizing damaged
tissue and for measuring the safety and efficacy of therapy. However, the ability to track the …

A review of responsive MRI contrast agents: 2005–2014

DV Hingorani, AS Bernstein… - Contrast media & …, 2015 - Wiley Online Library
This review focuses on MRI contrast agents that are responsive to a change in a
physiological biomarker. The response mechanisms are dependent on six physicochemical …

Basic MR relaxation mechanisms and contrast agent design

LM De León‐Rodríguez, AF Martins… - Journal of Magnetic …, 2015 - Wiley Online Library
The diagnostic capabilities of magnetic resonance imaging (MRI) have undergone
continuous and substantial evolution by virtue of hardware and software innovations and the …

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

M Tamaki, Y Fujitani, A Hara, T Uchida… - The Journal of …, 2013 - Am Soc Clin Investig
Recent genome-wide association studies demonstrated that common variants of solute
carrier family 30 member 8 gene (SLC30A8) increase susceptibility to type 2 diabetes …

Applications for transition-metal chemistry in contrast-enhanced magnetic resonance imaging

A Gupta, P Caravan, WS Price… - Inorganic …, 2020 - ACS Publications
Contrast-enhanced magnetic resonance imaging (MRI) is an indispensable tool for
diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI …

Large‐scale synthesis and medical applications of uniform‐sized metal oxide nanoparticles

HJ Kwon, K Shin, M Soh, H Chang, J Kim… - Advanced …, 2018 - Wiley Online Library
Thanks to recent advances in the synthesis of high‐quality inorganic nanoparticles, more
and more types of nanoparticles are becoming available for medical applications …