The intestinal epithelium has one of the highest rates of cellular turnover in a process that is
tightly regulated. As the transit-amplifying progenitors of the intestinal epithelium generate …

Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

KRAS is one of the most commonly mutated proteins in cancer, and efforts to directly inhibit
its function have been continuing for decades. The most successful of these has been the …

Despite more than three decades of intensive effort, no effective pharmacological inhibitors
of the RAS oncoproteins have reached the clinic, prompting the widely held perception that …

KRAS mutations are among the most common genetic alterations in lung, colorectal, and
pancreatic cancers. Direct inhibition of KRAS oncoproteins has been a long-standing pursuit …

NF-κB comprises a family of five transcription factors that form distinct protein complexes,
which bind to consensus DNA sequences at promoter regions of responsive genes …

For nearly a decade, the difficulties associated with both the determination and
reproducibility of Ras-dependency indexes (RDIs) have limited their application and further …

Cancer is a devastating disease process that touches the lives of millions worldwide.
Despite advances in our understanding of the genomic architecture of cancers and the …

Caspase-8 is an apical caspase involved in the programmed form of cell death called
apoptosis that is critically important for mammalian development and immunity. Apoptosis …

Oncogenic KRAS is the key driver of pancreatic ductal adenocarcinoma (PDAC). We
previously described a role for KRAS in PDAC tumor maintenance through rewiring of …