Opportunities and challenges in long-read sequencing data analysis

SL Amarasinghe, S Su, X Dong, L Zappia, ME Ritchie… - Genome biology, 2020 - Springer
Long-read technologies are overcoming early limitations in accuracy and throughput,
broadening their application domains in genomics. Dedicated analysis tools that take into …

[HTML][HTML] The impact of third generation genomic technologies on plant genome assembly

WB Jiao, K Schneeberger - Current opinion in plant biology, 2017 - Elsevier
Highlights•Plant genomes are more repetitive and complicate to assemble than
vertebrates.•Long-read assembly contigs outperform short-read assembly scaffolds.•Long …

SyRI: finding genomic rearrangements and local sequence differences from whole-genome assemblies

M Goel, H Sun, WB Jiao, K Schneeberger - Genome biology, 2019 - Springer
Genomic differences range from single nucleotide differences to complex structural
variations. Current methods typically annotate sequence differences ranging from SNPs to …

Chromosome-scale assemblies of plant genomes using nanopore long reads and optical maps

C Belser, B Istace, E Denis, M Dubarry, FC Baurens… - Nature plants, 2018 - nature.com
Plant genomes are often characterized by a high level of repetitiveness and polyploid
nature. Consequently, creating genome assemblies for plant genomes is challenging. The …

Pearl millet genome sequence provides a resource to improve agronomic traits in arid environments

RK Varshney, C Shi, M Thudi, C Mariac… - Nature …, 2017 - nature.com
Pearl millet [Cenchrus americanus (L.) Morrone] is a staple food for more than 90 million
farmers in arid and semi-arid regions of sub-Saharan Africa, India and South Asia. We report …

Haplotype-resolved genome analyses of a heterozygous diploid potato

Q Zhou, D Tang, W Huang, Z Yang, Y Zhang… - Nature …, 2020 - nature.com
Potato (Solanum tuberosum L.) is the most important tuber crop worldwide. Efforts are
underway to transform the crop from a clonally propagated tetraploid into a seed …

High-resolution comparative analysis of great ape genomes

ZN Kronenberg, IT Fiddes, D Gordon, S Murali… - Science, 2018 - science.org
INTRODUCTION Understanding the genetic differences that make us human is a long-
standing endeavor that requires the comprehensive discovery and comparison of all forms …

Identification of errors in draft genome assemblies at single-nucleotide resolution for quality assessment and improvement

K Li, P Xu, J Wang, X Yi, Y Jiao - Nature Communications, 2023 - nature.com
Assembly of a high-quality genome is important for downstream comparative and functional
genomic studies. However, most tools for genome assembly assessment only give …

Chromosome-level assemblies of multiple Arabidopsis genomes reveal hotspots of rearrangements with altered evolutionary dynamics

WB Jiao, K Schneeberger - Nature communications, 2020 - nature.com
Despite hundreds of sequenced Arabidopsis genomes, very little is known about the degree
of genomic collinearity within single species, due to the low number of chromosome-level …

Cicer super-pangenome provides insights into species evolution and agronomic trait loci for crop improvement in chickpea

AW Khan, V Garg, S Sun, S Gupta, O Dudchenko… - Nature …, 2024 - nature.com
Abstract Chickpea (Cicer arietinum L.)—an important legume crop cultivated in arid and
semiarid regions—has limited genetic diversity. Efforts are being undertaken to broaden its …