Virus‐like particles: Next‐generation nanoparticles for targeted therapeutic delivery

MJ Rohovie, M Nagasawa… - … & translational medicine, 2017 - Wiley Online Library
Most drug therapies distribute the agents throughout the entire body, even though the drugs
are typically only needed at specific tissues. This often limits dosage and causes discomfort …

Protein nanoparticles: promising platforms for drug delivery applications

A Jain, SK Singh, SK Arya, SC Kundu… - … Biomaterials Science & …, 2018 - ACS Publications
The development of drug delivery systems using nanoparticles as carriers for small and
large therapeutic molecules remains a rapidly growing area of research. The advantages of …

Design of virus-based nanomaterials for medicine, biotechnology, and energy

AM Wen, NF Steinmetz - Chemical Society Reviews, 2016 - pubs.rsc.org
This review provides an overview of recent developments in “chemical virology.” Viruses, as
materials, provide unique nanoscale scaffolds that have relevance in chemical biology and …

[HTML][HTML] Bacteriophage lambda: Early pioneer and still relevant

SR Casjens, RW Hendrix - Virology, 2015 - Elsevier
Molecular genetic research on bacteriophage lambda carried out during its golden age from
the mid-1950s to mid-1980s was critically important in the attainment of our current …

Protein cage assembly across multiple length scales

WM Aumiller, M Uchida, T Douglas - Chemical Society Reviews, 2018 - pubs.rsc.org
Within the materials science community, proteins with cage-like architectures are being
developed as versatile nanoscale platforms for use in protein nanotechnology. Much effort …

Virus-based nanoparticles as versatile nanomachines

KJ Koudelka, AS Pitek, M Manchester… - Annual review of …, 2015 - annualreviews.org
Nanoscale engineering is revolutionizing the way we prevent, detect, and treat diseases.
Viruses have played a special role in these developments because they can function as …

Functionalization of protein-based nanocages for drug delivery applications

L Schoonen, JCM van Hest - Nanoscale, 2014 - pubs.rsc.org
Traditional drug delivery strategies involve drugs which are not targeted towards the desired
tissue. This can lead to undesired side effects, as normal cells are affected by the drugs as …

Bioengineering strategies for protein-based nanoparticles

D Diaz, A Care, A Sunna - Genes, 2018 - mdpi.com
In recent years, the practical application of protein-based nanoparticles (PNPs) has
expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis …

Development of virus-like particle technology from small highly symmetric to large complex virus-like particle structures

P Pushko, P Pumpens, E Grens - Intervirology, 2013 - karger.com
Virus-like particle (VLP) technology is a promising approach for the construction of novel
vaccines, diagnostic tools, and gene therapy vectors. Initially, VLPs were primarily derived …

Modular self-assembly of protein cage lattices for multistep catalysis

M Uchida, K McCoy, M Fukuto, L Yang, H Yoshimura… - ACS …, 2018 - ACS Publications
The assembly of individual molecules into hierarchical structures is a promising strategy for
develo** three-dimensional materials with properties arising from interaction between the …