Neuronal microenvironment imbalance is associated with successive and irreversible
pathophysiological changes and insufficient functional restoration after peripheral nerve …

The homochirality of biomolecules in nature, such as DNA, RNA, peptides and proteins, has
played a critical role in establishing and sustaining life on Earth. This chiral bias has also …

KCNQ1 is the pore-forming subunit of cardiac slow-delayed rectifier potassium (I Ks)
channels. Mutations in the kcnq1 gene are the leading cause of congenital long QT …

The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-
current, which helps to stabilize the membrane potential. KCNQ2 can be activated by …

Potassium channels are transmembrane proteins that selectively facilitate the flow of
potassium ions down an electrochemical gradient. These molecules have been studied in …

Progressive myoclonus epilepsies (PMEs) are a group of rare, inherited disorders
manifesting with action myoclonus, tonic-clonic seizures and ataxia. We sequenced the …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …

The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is
an important drug target to treat epilepsy, pain and several other diseases related to …

Transmembrane receptors allow a cell to communicate with its environment in response to a
variety of input signals. These can be changes in the concentration of ligands (eg hormones …