Recruitment of enzymes to intracellular membranes often modulates their catalytic activity,
which can be important in cell signaling and membrane trafficking. Thus, re-localization is …

Lipid droplets (LDs) are intracellular storage organelles composed of neutral lipids, such as
triacylglycerol (TG), surrounded by a phospholipid (PL) monolayer decorated with specific …

While most of the articles in this issue review the workings of integral membrane enzymes, in
this review, we describe the catalytic mechanism of an enzyme that contains a soluble …

Phospholipids are the primary building blocks of biological membranes, are secreted in
protein–lipid complexes and serve as precursors in cell signalling. The functional diversity of …

Fatty acids stored in triacylglycerol-rich lipid droplets are assembled with a surface
monolayer composed primarily of phosphatidylcholine (PC). Fatty acids stimulate PC …

De novo phosphatidylcholine (PC) biosynthesis via the Kennedy pathway involves highly
endergonic biochemical reactions that must be fine-tuned with energy homeostasis …

CTP: phosphocholine cytidylyltransferase-alpha (CCTα) and CCTβ catalyze the rate-limiting
step in phosphatidylcholine (PC) biosynthesis. CCTα is activated by association of its α …

CTP phosphocholine cytidylyltransferase (CCT) is the key regulatory enzyme in
phosphatidylcholine (PC) synthesis and is activated by binding to PC-deficient membranes …

The development of the malaria parasite, Plasmodium falciparum, in the human erythrocyte,
relies on phospholipid metabolism to fulfil the massive need for membrane biogenesis …

The rate-limiting step in the biosynthesis of the major membrane phospholipid,
phosphatidylcholine, is catalyzed by CTP: phosphocholine cytidylyltransferase (CCT), which …