Magnesium is the fourth most abundant cation in the body and plays an important
physiological role in many of its functions. Magnesium balance is maintained by renal …

Cancer is the leading cause of mortality worldwide, accounting for almost 13% of deaths in
the world. Among the conventional cancer treatments, chemotherapy is most frequently …

Blood urea nitrogen and serum creatinine are imperfect markers of kidney function because
they are influenced by many renal and nonrenal factors independent of kidney function. A …

Cisplatin is currently one of the most widely-used chemotherapeutic agents against various
malignancies. Its clinical application is limited, however, by inherent renal and cardiac …

Nephrotoxicity is an inherent adverse effect of certain anticancer drugs. Renal dysfunction
can be categorised as prerenal uraemia, intrinsic damage or postrenal uraemia according to …

Cisplatin is one of the most active cytotoxic agents in the treatment of cancer, but its clinical
use is associated with nephrotoxicity. In the present study we report the effects of different …

Hypomagnesemia is a well known side-effect in patients receiving cisplatin-containing
chemotherapy. Cisplatin induces hypomagnesemia through its renal toxicity possibly by a …

Objective To determine which hydration (saline, saline+ mannitol, or saline+ furosemide) is
associated with least cisplatin nephrotoxicity. Methods We randomized 49 women who …

The effects of thymoquinone (TQ) on cisplatin-induced nephrotoxicity in mice and rats were
studied. Oral administration of TQ (50 mg/L in drinking water) for 5 days before and 5 days …

The effect of naringenin (NAR), a naturally occurring citrus flavanone, on the acute
nephrotoxicity produced by cisplatin (7 mg/kg, iv) was investigated in the rat. Oral …