Research progress of single-cell transcriptome sequencing in autoimmune diseases and autoinflammatory disease: A review

L Zeng, K Yang, T Zhang, X Zhu, W Hao, H Chen… - Journal of …, 2022 - Elsevier
Autoimmunity refers to the phenomenon that the body's immune system produces antibodies
or sensitized lymphocytes to its own tissues to cause an immune response. Immune …

Environmental pollutants and phosphoinositide signaling in autoimmunity

C Ren, ND Carrillo, VL Cryns, RA Anderson… - Journal of Hazardous …, 2024 - Elsevier
Environmental pollution stands as one of the most critical challenges affecting human
health, with an estimated mortality rate linked to pollution-induced non-communicable …

[HTML][HTML] CD4+ T-cell subsets in autoimmune hepatitis: A review

H Chen, Z Han, Y Fan, L Chen, F Peng… - Hepatology …, 2023 - journals.lww.com
Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that can lead to
hepatocyte destruction, inflammation, liver fibrosis, cirrhosis, and liver failure. The diagnosis …

[HTML][HTML] The role of amino acid metabolism in autoimmune hepatitis

X **ang, Q Li, J Wan, C Chen, M Guo, Z He… - Biomedicine & …, 2024 - Elsevier
Autoimmune hepatitis (AIH) is an inflammatory chronic liver disease with persistent and
recurrent immune-mediated liver injury. The exact cause of AIH is still not fully understood …

Research progress on the application of single-cell sequencing in autoimmune diseases

X Yang, X Hou, J Zhang, Z Liu, G Wang - Genes & Immunity, 2023 - nature.com
Autoimmune diseases (AIDs) are caused by immune tolerance deficiency or abnormal
immune regulation, leading to damage to host organs. The complicated pathogenesis and …

Identification of miRNAs that target Fcγ receptor-mediated phagocytosis during macrophage activation syndrome

KK Varsha, X Yang, AS Cannon, Y Zhong… - Frontiers in …, 2024 - frontiersin.org
Macrophage activation syndrome (MAS) is a life-threatening complication of systemic
juvenile arthritis, accompanied by cytokine storm and hemophagocytosis. In addition, COVID …

Natural killer cells, as the rising point in tissues, are forgotten in the kidney

K Ma, ZR Zheng, Y Meng - Biomolecules, 2023 - mdpi.com
Natural killer (NK) cells are members of a rapidly expanding family of innate lymphoid cells
(ILCs). NK cells play roles in the spleen, periphery, and in many tissues, such as the liver …

6-Formylindolo [3, 2-b] carbazole, a potent ligand for the aryl hydrocarbon receptor, attenuates concanavalin-induced hepatitis by limiting T-cell activation and …

AS Cannon, BL Holloman, K Wilson… - Journal of Leukocyte …, 2024 - academic.oup.com
Abstract FICZ (6-formylindolo [3, 2-b] carbazole) is a potent aryl hydrocarbon receptor
agonist that has a poorly understood function in the regulation of inflammation. In this study …

Engaging natural regulatory myeloid cells to restrict T-cell hyperactivation-induced liver inflammation via extracellular vesicle-mediated purine metabolism regulation

F Yang, R Men, L Lv, L Zhou, Q Deng, X Wang… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Dysregulated T-cell immune response-mediated inflammation plays critical roles
in the pathology of diverse liver diseases, but the underlying mechanism of liver immune …

Bioluminescence imaging of Cyp1a1-luciferase reporter mice demonstrates prolonged activation of the aryl hydrocarbon receptor in the lung

N Veland, HJ Gleneadie, KE Brown, A Sardini… - Communications …, 2024 - nature.com
Aryl hydrocarbon receptor (AHR) signalling integrates biological processes that sense and
respond to environmental, dietary, and metabolic challenges to ensure tissue homeostasis …