DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

DNA methylation is prevalent in mammalian genomes and plays a central role in the
epigenetic control of development. The mammalian DNA methylation machinery is thought …

Long interspersed nuclear elements 1 (L1 elements or LINE1) are the most active
autonomous retrotransposons in mammalian genomes. In addition to L1 elements …

Transcriptional silencing by heritable cytosine-5 methylation is an ancient strategy to repress
transposable elements. It was previously thought that mammals possess four DNA …

Transcriptional silencing of retrotransposons via DNA methylation is paramount for
mammalian fertility and reproductive fitness. During germ cell development, most …

Abstract DNA methyltransferase (DNMT) 3A and DNMT3B are both active de novo DNA
methyltransferases required for development, whereas DNMT3L, which has no …

The flavin monooxygenase (FMO) enzyme was discovered in mammalian liver cells that
convert a carcinogenic compound, NN′-dimethylaniline, into a non-carcinogenic …

In 1993, Denise Barlow proposed that genomic imprinting might have arisen from a host
defense mechanism designed to inactivate retrotransposons. Although there were few …

BACKGROUND: Dnmt3L, a member of the DNA methyltransferase 3 family, lacks enzymatic
activity but is required for de-novo methylation of imprinted genes in oocytes and for …

Obesity is a complex disease which has reached epidemic dimensions. Thus, prevention of
excessive weight gain and associated metabolic and cardiovascular diseases has to start as …