Neuregulin-1, a potential therapeutic target for cardiac repair

Y Wang, J Wei, P Zhang, X Zhang, Y Wang… - Frontiers in …, 2022 - frontiersin.org
NRG1 (Neuregulin-1) is an effective cardiomyocyte proliferator, secreted and released by
endothelial vascular cells, and affects the cardiovascular system. It plays a major role in …

Myelin repair in Alzheimer's disease: a review of biological pathways and potential therapeutics

LR Hirschfeld, SL Risacher, K Nho… - Translational …, 2022 - Springer
This literature review investigates the significant overlap between myelin-repair signaling
pathways and pathways known to contribute to hallmark pathologies of Alzheimer's disease …

Neuregulins in neurodegenerative diseases

G Ou, W Lin, W Zhao - Frontiers in aging neuroscience, 2021 - frontiersin.org
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD)
and amyotrophic lateral sclerosis (ALS), are typically characterized by progressive neuronal …

The mechanisms of perineuronal net abnormalities in contributing aging and neurological diseases

Y Dong, K Zhao, X Qin, G Du, L Gao - Ageing Research Reviews, 2023 - Elsevier
The perineuronal net (PNN) is a highly latticed extracellular matrix in the central nervous
system, which is composed of hyaluronic acid, proteoglycan, hyaluronan and proteoglycan …

USP2-related cellular signaling and consequent pathophysiological outcomes

H Kitamura, M Hashimoto - International journal of molecular sciences, 2021 - mdpi.com
Ubiquitin specific protease (USP) 2 is a multifunctional deubiquitinating enzyme. USP2
modulates cell cycle progression, and therefore carcinogenesis, via the deubiquitination of …

Mechanisms of the multitasking endothelial protein NRG-1 as a compensatory factor during chronic heart failure

GW De Keulenaer, E Feyen, L Dugaucquier… - Circulation: Heart …, 2019 - Am Heart Assoc
Heart failure is a complex syndrome whose phenotypic presentation and disease
progression depends on a complex network of adaptive and maladaptive responses. One of …

Stem cell scaffolds for the treatment of spinal cord injury—a review

G Hey, M Willman, A Patel, M Goutnik, J Willman… - Biomechanics, 2023 - mdpi.com
Spinal cord injury (SCI) is a profoundly debilitating yet common central nervous system
condition resulting in significant morbidity and mortality rates. Major causes of SCI …

Epidermal growth factor in the CNS: a beguiling journey from integrated cell biology to multiple sclerosis. An extensive translational overview

G Scalabrino - Cellular and Molecular Neurobiology, 2022 - Springer
This article reviews the wealth of papers dealing with the different effects of epidermal
growth factor (EGF) on oligodendrocytes, astrocytes, neurons, and neural stem cells (NSCs) …

Dysfunction of NRG1/ErbB4 signaling in the Hippocampus might mediate long-term memory decline after systemic inflammation

Y Gao, X Wu, Z Zhou, P Liu, J Yang, M Ji - Molecular Neurobiology, 2023 - Springer
Accumulating evidence has suggested that a great proportion of sepsis survivors suffer from
long-term cognitive impairments after hospital discharge, leading to decreased life quality …

Neuregulin 1 mitigated prolactin deficiency through enhancing TRPM8 signaling under the influence of melatonin in senescent pituitary lactotrophs

W Zhang, J Dao, Q Li, C Liu, C Qiao, C Cui… - International Journal of …, 2024 - Elsevier
The age-related alterations in pituitary function, including changes in prolactin (PRL)
production contributes to the systemic susceptibility to age-related diseases. Our previous …