How transcription factors drive choice of the T cell fate
H Hosokawa, EV Rothenberg - Nature Reviews Immunology, 2021 - nature.com
Recent evidence has elucidated how multipotent blood progenitors transform their identities
in the thymus and undergo commitment to become T cells. Together with environmental …
in the thymus and undergo commitment to become T cells. Together with environmental …
Human NK cell development: one road or many?
F Cichocki, B Grzywacz, JS Miller - Frontiers in immunology, 2019 - frontiersin.org
CD3− CD56+ NK cells develop from CD34+ hematopoietic progenitors (HPCs) in vivo, and
this process can be recapitulated in vitro. The prevailing model is that human NK cell …
this process can be recapitulated in vitro. The prevailing model is that human NK cell …
The role of exome sequencing in newborn screening for inborn errors of metabolism
AN Adhikari, RC Gallagher, Y Wang, RJ Currier… - Nature medicine, 2020 - nature.com
Public health newborn screening (NBS) programs provide population-scale ascertainment
of rare, treatable conditions that require urgent intervention. Tandem mass spectrometry …
of rare, treatable conditions that require urgent intervention. Tandem mass spectrometry …
Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California, 2010–2017
GS Amatuni, RJ Currier, JA Church, T Bishop… - …, 2019 - publications.aap.org
OBJECTIVES: Newborn screening for severe combined immunodeficiency (SCID) was
instituted in California in 2010. In the ensuing 6.5 years, 3 252 156 infants in the state had …
instituted in California in 2010. In the ensuing 6.5 years, 3 252 156 infants in the state had …
Newborn screening for severe combined immunodeficiency and T‐cell lymphopenia
JM Puck - Immunological reviews, 2019 - Wiley Online Library
The development of a T cell receptor excision circle (TREC) assay utilizing dried blood spots
(DBS) made possible universal newborn screening (NBS) for severe combined …
(DBS) made possible universal newborn screening (NBS) for severe combined …
SCID newborn screening: what we've learned
R Currier, JM Puck - Journal of Allergy and Clinical Immunology, 2021 - Elsevier
Newborn screening for severe combined immunodeficiency, the most profound form of
primary immune system defects, has long been recognized as a measure that would …
primary immune system defects, has long been recognized as a measure that would …
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation
TD Holmes, RV Pandey, EY Helm, H Schlums… - Science …, 2021 - science.org
Epigenetic landscapes can provide insight into regulation of gene expression and cellular
diversity. Here, we examined the transcriptional and epigenetic profiles of seven human …
diversity. Here, we examined the transcriptional and epigenetic profiles of seven human …
A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS
M Yamashita, HS Kuehn, K Okuyama, S Okada… - Nature …, 2021 - nature.com
In the present study, we report a human-inherited, impaired, adaptive immunity disorder,
which predominantly manifested as a B cell differentiation defect, caused by a heterozygous …
which predominantly manifested as a B cell differentiation defect, caused by a heterozygous …
BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells
D Lessel, C Gehbauer, NC Bramswig… - Brain, 2018 - academic.oup.com
The transcription factor BCL11B is essential for development of the nervous and the immune
system, and Bcl11b deficiency results in structural brain defects, reduced learning capacity …
system, and Bcl11b deficiency results in structural brain defects, reduced learning capacity …
Genetic architectures of proximal and distal colorectal cancer are partly distinct
Objective An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is
critical for improving precision prevention, including individualized screening …
critical for improving precision prevention, including individualized screening …