Leloir glycosyltransferases in applied biocatalysis: A multidisciplinary approach

L Mestrom, M Przypis, D Kowalczykiewicz… - International Journal of …, 2019 - mdpi.com
Enzymes are nature's catalyst of choice for the highly selective and efficient coupling of
carbohydrates. Enzymatic sugar coupling is a competitive technology for industrial …

Magnetic micro-macro biocatalysts applied to industrial bioprocesses

J Del Arco, AR Alcántara, R Fernández-Lafuente… - Bioresource …, 2021 - Elsevier
The use of magnetic biocatalysts is highly beneficial in bioprocesses technology, as it allows
their easy recovering and enhances biocatalyst lifetime. Thus, it simplifies operational …

Engineered ribosyl-1-kinase enables concise synthesis of molnupiravir, an antiviral for COVID-19

JA McIntosh, T Benkovics, SM Silverman… - ACS central …, 2021 - ACS Publications
Molnupiravir (MK-4482) is an investigational antiviral agent that is under development for
the treatment of COVID-19. Given the potential high demand and urgency for this compound …

Biocatalysis in the pharmaceutical industry: the need for speed

MD Truppo - ACS medicinal chemistry letters, 2017 - ACS Publications
The use of biocatalysis in the pharmaceutical industry continues to expand as a result of
increased access to enzymes and the ability to engineer those enzymes to meet the …

Biocatalytic routes to anti-viral agents and their synthetic intermediates

S Slagman, WD Fessner - Chemical Society Reviews, 2021 - pubs.rsc.org
With recent outbreaks of COVID-19 and Ebola, health and healthcare have once more
shown to be heavily burdened by the lack of generally effective anti-viral therapies. Initial …

Designing an Efficient Biocatalyst for the Phosphoribosylation of Antiviral Pyrazine-2-carboxamide Derivatives

EA Zayats, IV Fateev, YA Abramchik… - ACS …, 2024 - ACS Publications
The development of technologies for the efficient synthesis of innovative antiviral
compounds remains an important challenge for modern biotechnology, especially in the …

New developments in nucleoside analogues biosynthesis: A review

MJ Lapponi, CW Rivero, MA Zinni, CN Britos… - Journal of Molecular …, 2016 - Elsevier
The present review deals with current advances in the chemoenzymatic synthesis of
biologically important nucleoside analogues (NA), either by the use of microorganisms or …

New trends in the biocatalytic production of nucleosidic active pharmaceutical ingredients using 2′-deoxyribosyltransferases

J Del Arco, J Acosta, J Fernández-Lucas - Biotechnology Advances, 2021 - Elsevier
Nowadays, pharmaceutical industry demands competitive and eco-friendly processes for
active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole …

Systematic comparison of co-expression of multiple recombinant thermophilic enzymes in Escherichia coli BL21(DE3)

H Chen, R Huang, YHP Zhang - Applied microbiology and biotechnology, 2017 - Springer
The precise control of multiple heterologous enzyme expression levels in one Escherichia
coli strain is important for cascade biocatalysis, metabolic engineering, synthetic biology …

Enzymatic Synthesis of Therapeutic Nucleosides using a Highly Versatile Purine Nucleoside 2'‐DeoxyribosylTransferase from Trypanosoma brucei

E Pérez, PA Sánchez‐Murcia, J Jordaan… - …, 2018 - Wiley Online Library
The use of enzymes for the synthesis of nucleoside analogues offers several advantages
over multistep chemical methods, including chemo‐, regio‐and stereoselectivity as well as …