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Leloir glycosyltransferases in applied biocatalysis: A multidisciplinary approach
L Mestrom, M Przypis, D Kowalczykiewicz… - International Journal of …, 2019 - mdpi.com
Enzymes are nature's catalyst of choice for the highly selective and efficient coupling of
carbohydrates. Enzymatic sugar coupling is a competitive technology for industrial …
carbohydrates. Enzymatic sugar coupling is a competitive technology for industrial …
Magnetic micro-macro biocatalysts applied to industrial bioprocesses
The use of magnetic biocatalysts is highly beneficial in bioprocesses technology, as it allows
their easy recovering and enhances biocatalyst lifetime. Thus, it simplifies operational …
their easy recovering and enhances biocatalyst lifetime. Thus, it simplifies operational …
Engineered ribosyl-1-kinase enables concise synthesis of molnupiravir, an antiviral for COVID-19
JA McIntosh, T Benkovics, SM Silverman… - ACS central …, 2021 - ACS Publications
Molnupiravir (MK-4482) is an investigational antiviral agent that is under development for
the treatment of COVID-19. Given the potential high demand and urgency for this compound …
the treatment of COVID-19. Given the potential high demand and urgency for this compound …
Biocatalysis in the pharmaceutical industry: the need for speed
MD Truppo - ACS medicinal chemistry letters, 2017 - ACS Publications
The use of biocatalysis in the pharmaceutical industry continues to expand as a result of
increased access to enzymes and the ability to engineer those enzymes to meet the …
increased access to enzymes and the ability to engineer those enzymes to meet the …
Biocatalytic routes to anti-viral agents and their synthetic intermediates
With recent outbreaks of COVID-19 and Ebola, health and healthcare have once more
shown to be heavily burdened by the lack of generally effective anti-viral therapies. Initial …
shown to be heavily burdened by the lack of generally effective anti-viral therapies. Initial …
Designing an Efficient Biocatalyst for the Phosphoribosylation of Antiviral Pyrazine-2-carboxamide Derivatives
EA Zayats, IV Fateev, YA Abramchik… - ACS …, 2024 - ACS Publications
The development of technologies for the efficient synthesis of innovative antiviral
compounds remains an important challenge for modern biotechnology, especially in the …
compounds remains an important challenge for modern biotechnology, especially in the …
New developments in nucleoside analogues biosynthesis: A review
MJ Lapponi, CW Rivero, MA Zinni, CN Britos… - Journal of Molecular …, 2016 - Elsevier
The present review deals with current advances in the chemoenzymatic synthesis of
biologically important nucleoside analogues (NA), either by the use of microorganisms or …
biologically important nucleoside analogues (NA), either by the use of microorganisms or …
New trends in the biocatalytic production of nucleosidic active pharmaceutical ingredients using 2′-deoxyribosyltransferases
Nowadays, pharmaceutical industry demands competitive and eco-friendly processes for
active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole …
active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole …
Systematic comparison of co-expression of multiple recombinant thermophilic enzymes in Escherichia coli BL21(DE3)
H Chen, R Huang, YHP Zhang - Applied microbiology and biotechnology, 2017 - Springer
The precise control of multiple heterologous enzyme expression levels in one Escherichia
coli strain is important for cascade biocatalysis, metabolic engineering, synthetic biology …
coli strain is important for cascade biocatalysis, metabolic engineering, synthetic biology …
Enzymatic Synthesis of Therapeutic Nucleosides using a Highly Versatile Purine Nucleoside 2'‐DeoxyribosylTransferase from Trypanosoma brucei
The use of enzymes for the synthesis of nucleoside analogues offers several advantages
over multistep chemical methods, including chemo‐, regio‐and stereoselectivity as well as …
over multistep chemical methods, including chemo‐, regio‐and stereoselectivity as well as …