Abstract Knowledge of the three-dimensional structures of protein targets now emerging
from genomic data has the potential to accelerate drug discovery greatly. X-ray …

Transthyretin (TTR) belongs to a group of proteins, which includes thyroxine-binding
globulin and albumin, that bind to and transport thyroid hormones in the blood. TTR is also …

FUGUE, a program for recognizing distant homologues by sequence-structure comparison
(http://www-cryst. bioc. cam. ac. uk/fugue/), has three key features.(1) Improved environment …

GABAA receptors are chloride ion channels that mediate fast synaptic transmission and
belong to a superfamily of pentameric ligand-gated ion channels. The recently published …

Mal d 2 is a thaumatin-like protein and important allergen of apple fruits that is associated
with IgE-mediated symptoms in apple allergic individuals. We obtained a full-length cDNA …

Motivation: Multiple structure alignments are becoming important tools in many aspects of
structural bioinformatics. The current explosion in the number of available protein structures …

The 3D models of both CB1 and CB2 human receptors have been established by homology
modeling using as template the X-ray structure of bovine Rhodopsin (code pdb: 1F88) a G …

Abstract Motivation: Membrane proteins (MPs) are important drug targets but knowledge of
their exact structure is limited to relatively few examples. Existing homology-based structure …

Serine hydroxymethyltransferase (SHMT) is a member of the fold type I family of vitamin B6‐
dependent enzymes, a group of evolutionarily related proteins that share the same overall …

In biofilms, the bacterial community optimizes the strategies to sense the environment and to
communicate from cell to cell. A key player in the development of a bacterial biofilm is the …