Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

The use of probiotics by cancer patients is increasing, including among those undergoing
immune checkpoint inhibitor (ICI) treatment. Here, we elucidate a critical microbial-host …

Immune tolerance deletes or suppresses autoreactive lymphocytes and is established at
multiple levels during the development, activation and effector phases of T and B cells …

The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that can result in
substantial morbidity and mortality. Diagnosis and treatment of SLE are clinical challenges …

Human microorganisms, including bacteria, fungi, and viruses, play key roles in several
physiological and pathological processes. Some studies discovered that tumour tissues …

The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …

Approximately 5% of the world-wide population is affected by autoimmune diseases.
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …

Gut commensal bacteria with the ability to translocate across the intestinal barrier can drive
the development of diverse immune-mediated diseases,,–. However, the key factors that …