Cancer, which is the uncontrolled growth of cells, is the second leading cause of death after
heart disease. Targeting drugs, especially to specific genes and proteins involved in growth …

α, β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in
medicinal chemistry, especially in the identification and development of potential anticancer …

Herein we report the anaerobic cleavage of alkenes into carbonyl compounds using
nitroarenes as oxygen transfer reagents under visible light. This approach serves as a safe …

It is over 50 years since the discovery of microtubules, and they have become one of the
most important drug targets for anti-cancer therapies. Microtubules are predominantly …

Quinoline is an efficient scaffold for anticancer drug development as its derivatives have
shown potent results through several mechanisms like growth regulators through “apoptosis …

The vital roles of microtubule in mitosis and cell division make it an attractive target for
antitumor therapy. Colchicine binding site of tubulin is one of the most important pockets that …

A series of novel quinoline–chalcone derivatives were designed, synthesized, and
evaluated for their antiproliferative activity. Among them, compound 24d exhibited the most …

N-Sulfonyl hydrazones have been extensively used as operationally safe carbene
precursors in modern organic synthesis due to their ready availability, facile …

A new series of quinoline-chalcone hybrids was synthesized. The structures of these
compounds were characterized by spectroscopic methods including 1 H and 13 CNMR and …

Tubulin, an important clinical molecular target, has attracted high attention in drug design
development and cancer treatment. Tubulin inhibitors cause cell cycle arrest in the G 2/M …