Microbiome-based therapeutics
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
Microbiota-mediated colonization resistance: mechanisms and regulation
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …
The person-to-person transmission landscape of the gut and oral microbiomes
The human microbiome is an integral component of the human body and a co-determinant
of several health conditions,. However, the extent to which interpersonal relations shape the …
of several health conditions,. However, the extent to which interpersonal relations shape the …
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases
Fecal microbiota transplantation (FMT) is highly effective against recurrent Clostridioides
difficile infection and is considered a promising treatment for other microbiome-related …
difficile infection and is considered a promising treatment for other microbiome-related …
Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients
The gut microbiome has been shown to influence the response of tumors to anti–PD-1
(programmed cell death–1) immunotherapy in preclinical mouse models and observational …
(programmed cell death–1) immunotherapy in preclinical mouse models and observational …
Key determinants of success in fecal microbiota transplantation: From microbiome to clinic
Fecal microbiota transplantation (FMT) has achieved satisfactory results in preventing the
recurrence of Clostridioides difficile infection, but these positive outcomes have only been …
recurrence of Clostridioides difficile infection, but these positive outcomes have only been …
inStrain profiles population microdiversity from metagenomic data and sensitively detects shared microbial strains
Coexisting microbial cells of the same species often exhibit genetic variation that can affect
phenotypes ranging from nutrient preference to pathogenicity. Here we present inStrain, a …
phenotypes ranging from nutrient preference to pathogenicity. Here we present inStrain, a …
[HTML][HTML] Elevated rates of horizontal gene transfer in the industrialized human microbiome
Industrialization has impacted the human gut ecosystem, resulting in altered microbiome
composition and diversity. Whether bacterial genomes may also adapt to the …
composition and diversity. Whether bacterial genomes may also adapt to the …
Microbial genes and pathways in inflammatory bowel disease
Perturbations in the intestinal microbiome are implicated in inflammatory bowel disease
(IBD). Studies of treatment-naive patients have identified microbial taxa associated with …
(IBD). Studies of treatment-naive patients have identified microbial taxa associated with …
Machine learning for microbiologists
Abstract Machine learning is increasingly important in microbiology where it is used for tasks
such as predicting antibiotic resistance and associating human microbiome features with …
such as predicting antibiotic resistance and associating human microbiome features with …