Common and rare variant associations with clonal haematopoiesis phenotypes
Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been
associated with ageing and adverse health outcomes,,,–. Here we use exome sequence …
associated with ageing and adverse health outcomes,,,–. Here we use exome sequence …
[HTML][HTML] Clonal dynamics of haematopoiesis across the human lifespan
E Mitchell, M Spencer Chapman, N Williams… - Nature, 2022 - nature.com
Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis
SN Stacey, F Zink, GH Halldorsson, L Stefansdottir… - Nature Genetics, 2023 - nature.com
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets
Clonal hematopoiesis of indeterminate potential (CHIP) is a common form of age-related
somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations …
somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations …
Minimal residual disease as a target for liquid biopsy in patients with solid tumours
K Pantel, C Alix-Panabières - Nature Reviews Clinical Oncology, 2024 - nature.com
Metastasis is the leading cause of cancer-related death in patients with solid tumours.
Current imaging technologies are not sufficiently sensitive to detect minimal residual …
Current imaging technologies are not sufficiently sensitive to detect minimal residual …
Distinct landscape and clinical implications of therapy-related clonal hematopoiesis
Therapy-related clonal hematopoiesis (t-CH) is defined as clonal hematopoiesis detected in
individuals previously treated with chemotherapy and/or radiation therapy. With the …
individuals previously treated with chemotherapy and/or radiation therapy. With the …
Tracking the evolution of therapy-related myeloid neoplasms using chemotherapy signatures
B Diamond, B Ziccheddu, K Maclachlan… - Blood, The Journal …, 2023 - ashpublications.org
Patients treated with cytotoxic therapies, including autologous stem cell transplantation, are
at risk for develo** therapy-related myeloid neoplasms (tMN). Preleukemic clones (ie …
at risk for develo** therapy-related myeloid neoplasms (tMN). Preleukemic clones (ie …
Dynamics of age-versus therapy-related clonal hematopoiesis in long-term survivors of pediatric cancer
We present the first comprehensive investigation of clonal hematopoiesis (CH) in 2,860 long-
term survivors of pediatric cancer with a median follow-up time of 23.5 years. Deep …
term survivors of pediatric cancer with a median follow-up time of 23.5 years. Deep …
DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells
Upon stimulation by extrinsic stimuli, stem cells initiate a programme that enables
differentiation or self-renewal. Disruption of the stem state exit has catastrophic …
differentiation or self-renewal. Disruption of the stem state exit has catastrophic …
Clonal hematopoiesis in clinical and experimental heart failure with preserved ejection fraction
BACKGROUND: Clonal hematopoiesis (CH), which results from an array of nonmalignant
driver gene mutations, can lead to altered immune cell function and chronic disease, and …
driver gene mutations, can lead to altered immune cell function and chronic disease, and …