The dynamics and interactions of cellular organelles underlie many aspects of cellular
functioning. Until recently, assessment of organelle dynamics has been primarily …

Two mechanisms have been proposed for the function of motor proteins: The power stroke
and the Brownian ratchet. The former refers to generation of a large downhill free energy …

Neurotropic alphaherpesviruses initiate infection in exposed mucosal tissues and, unlike
most viruses, spread rapidly to sensory and autonomic nerves where life-long latency is …

The kinesin-3 motor KIF1A functions in neurons, where its fast and superprocessive motility
facilitates long-distance transport, but little is known about its force-generating properties …

Kinesins drive the transport of cellular cargoes as they walk along microtubule tracks;
however, recent work has suggested that the physical act of kinesins walking along …

The trafficking of components within cilia, called intraflagellar transport (IFT), is powered by
kinesin-2 and dynein-2 motors. Loss of function in any subunit of the heterotrimeric …

Highlights•Cytoskeletal molecular motors are profound bionanotechnological devices.•The
mechanisms of these motors enable re-purposing and re-engineering.•They also provide …

Actin and microtubules play essential roles in aberrant cell processes that define and
converge in cancer including: signaling, morphology, motility, and division. Actin and …

Kinesin motor proteins that drive intracellular transport share an overall architecture of two
motor domain-containing subunits that dimerize through a coiled-coil stalk. Dimerization …

Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the
motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle …