Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
degeneration of the substantia nigra pars compacta and by accumulation of α-synuclein in …

Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …

The gut microbiota is emerging as an important modulator of neurodegenerative diseases,
and accumulating evidence has linked gut microbes to Parkinson's disease (PD) …

Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …

Common variant genome-wide association studies (GWASs) have, to date, identified> 24
risk loci for Parkinson's disease (PD). To discover additional loci, we carried out a GWAS …

Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

Inflammation is a protective reaction activated in response to detrimental stimuli, such as
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …

Parkinson's disease (PD) is a typical neurodegenerative disease and the pathological
feature of which is the death of dopamine neurons in the substantia nigra region. At present …

Microglia, the resident immune cells in the brain, are essential for modulating neurogenesis,
influencing synaptic remodeling, and regulating neuroinflammation by surveying the brain …

Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …