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Measuring biological age using omics data
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …
related diseases and increase healthspan have suggested targeting the ageing process …
Sex differences in biological aging with a focus on human studies
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, sha** the individual's aging trajectory and subsequent disease risks. There …
the life course, sha** the individual's aging trajectory and subsequent disease risks. There …
DNA methylation GrimAge version 2
We previously described a DNA methylation (DNAm) based biomarker of human mortality
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis
Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood …
by somatic driver mutations, affects over a third of people, yet remains poorly understood …
DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
Causality-enriched epigenetic age uncouples damage and adaptation
Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …
age but often lack causal insights. By harnessing large-scale genetic data through …
Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging
The concept of aging is complex, including many related phenotypes such as healthspan,
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …
Physical activity is associated with slower epigenetic ageing—Findings from the Rhineland study
Epigenetic ageing, ie, age‐associated changes in DNA methylation patterns, is a sensitive
marker of biological ageing, a major determinant of morbidity and functional decline. We …
marker of biological ageing, a major determinant of morbidity and functional decline. We …
Multi-ancestry meta-analysis and fine-map** in Alzheimer's disease
Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried
out in European ancestry individuals despite the known variation in genetic architecture and …
out in European ancestry individuals despite the known variation in genetic architecture and …
Identification of a longevity gene through evolutionary rate covariation of insect mito-nuclear genomes
M Tao, J Chen, C Cui, Y Xu, J Xu, Z Shi, J Yun, J Zhang… - Nature Aging, 2024 - nature.com
Oxidative phosphorylation, essential for energy metabolism and linked to the regulation of
longevity, involves mitochondrial and nuclear genes. The functions of these genes and their …
longevity, involves mitochondrial and nuclear genes. The functions of these genes and their …