GPX4 at the crossroads of lipid homeostasis and ferroptosis

GC Forcina, SJ Dixon - Proteomics, 2019‏ - Wiley Online Library
Oxygen is necessary for aerobic metabolism but can cause the harmful oxidation of lipids
and other macromolecules. Oxidation of cholesterol and phospholipids containing …

Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease

G Svegliati-Baroni, I Pierantonelli, P Torquato… - Free Radical Biology …, 2019‏ - Elsevier
Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver
disease worldwide (about 25% of the general population) and 3–5% of patients develop non …

[HTML][HTML] Updating Phospholipase A2 Biology

M Murakami, H Sato, Y Taketomi - Biomolecules, 2020‏ - mdpi.com
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …

Oxygen toxicity: cellular mechanisms in normobaric hyperoxia

R Alva, M Mirza, A Baiton, L Lazuran… - Cell Biology and …, 2023‏ - Springer
In clinical settings, oxygen therapy is administered to preterm neonates and to adults with
acute and chronic conditions such as COVID-19, pulmonary fibrosis, sepsis, cardiac arrest …

Lipid quality control and ferroptosis: from concept to mechanism

Z Li, M Lange, SJ Dixon… - Annual review of …, 2023‏ - annualreviews.org
Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …

The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond

M Murakami - Pharmacology & Therapeutics, 2023‏ - Elsevier
Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …

Identification of PRDX6 as a regulator of ferroptosis

B Lu, X Chen, Y Hong, H Zhu, Q He, B Yang… - Acta Pharmacologica …, 2019‏ - nature.com
Ferroptosis is a newly characterized iron-dependent form of nonapoptotic regulated cell
death triggered by lipid reactive oxygen species (LOOH). The dysregulation of ferroptosis is …

Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo

D Dibra, S **ong, SM Moyer, AK El-Naggar, Y Qi… - Science …, 2024‏ - science.org
The TP53 tumor suppressor gene is mutated early in most of the patients with triple-negative
breast cancer (TNBC). The most frequent TP53 alterations are missense mutations that …

The role of peroxiredoxin 6 in cell signaling

JA Arevalo, JP Vázquez-Medina - Antioxidants, 2018‏ - mdpi.com
Peroxiredoxin 6 (Prdx6, 1-cys peroxiredoxin) is a unique member of the peroxiredoxin family
that, in contrast to other mammalian peroxiredoxins, lacks a resolving cysteine and uses …

Zwitterions and betaines as highly soluble materials for sustainable corrosion protection: Interfacial chemistry and bonding with metal surfaces

C Verma, S Dubey, R Bose, A Alfantazi… - Advances in Colloid and …, 2024‏ - Elsevier
The primary requirements for interfacial adsorption and corrosion inhibition are solubility
and the existence of polar functional groups, particularly charges. Traditional organic …