Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …

The majority of therapeutics target membrane proteins, accessible on the surface of cells, to
alter cellular signaling. Cells use membrane proteins to transduce signals into cells …

Cellular protrusions, invaginations, and many intracellular organelles have strongly curved
membrane regions. Transmembrane and peripheral membrane proteins that induce, sense …

Abstract The Orientations of Proteins in Membranes (OPM) database is a curated web
resource that provides spatial positions of membrane-bound peptides and proteins of known …

Transmembrane α-helices in integral membrane proteins are recognized co-translationally
and inserted into the membrane of the endoplasmic reticulum by the Sec61 translocon. A full …

The design of functional membrane proteins from first principles represents a grand
challenge in chemistry and structural biology. Here, we report the design of a membrane …

The growing prevalence of resistance to antibiotics motivates the search for new
antibacterial agents. Antimicrobial peptides are a diverse class of well-studied membrane …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

We have implemented the mo lecular d esign l aboratory'sa nti m icrobial p eptides package
(modlAMP), a Python-based software package for the design, classification and visual …

Transmembrane (TM) domains as simple as a single span can perform complex biological
functions using entirely lipid-embedded chemical features. Computational design has the …