Type 2 diabetes mellitus
RA DeFronzo, E Ferrannini, L Groop… - Nature reviews Disease …, 2015 - nature.com
Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …
Signaling pathways in obesity: mechanisms and therapeutic interventions
X Wen, B Zhang, B Wu, H **ao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …
excessive fat accumulation in the body, obesity sharply increases the risk of several …
[HTML][HTML] Therapeutic advances of miRNAs: A preclinical and clinical update
Background miRNAs, a class of small endogenous RNAs, are one of the essential
biopharmaceuticals which are in commercial spans as next-generation medicine in recent …
biopharmaceuticals which are in commercial spans as next-generation medicine in recent …
Diagnostic, prognostic, and mechanistic biomarkers of diabetes mellitus-associated cognitive decline
Cognitive dysfunctions such as mild cognitive impairment (MCI), Alzheimer's disease (AD),
and other forms of dementia are recognized as common comorbidities of type 2 diabetes …
and other forms of dementia are recognized as common comorbidities of type 2 diabetes …
Discovering the Secret of Diseases by Incorporated Tear Exosomes Analysis via Rapid-Isolation System: iTEARS
L Hu, T Zhang, H Ma, Y Pan, S Wang, X Liu, X Dai… - ACS …, 2022 - ACS Publications
Nanoscale small extracellular vesicles (sEVs, exosomes) in tears allow us to investigate the
multisignatures of diseases. However, the translations of tear sEVs for biomarker discovery …
multisignatures of diseases. However, the translations of tear sEVs for biomarker discovery …
The pathogenesis of diabetes
H Guo, H Wu, Z Li - International journal of molecular sciences, 2023 - mdpi.com
Diabetes is the most common metabolic disorder, with an extremely serious effect on health
systems worldwide. It has become a severe, chronic, non-communicable disease after …
systems worldwide. It has become a severe, chronic, non-communicable disease after …
[HTML][HTML] MiR-27a promotes insulin resistance and mediates glucose metabolism by targeting PPAR-γ-mediated PI3K/AKT signaling
T Chen, Y Zhang, Y Liu, D Zhu, J Yu, G Li, Z Sun… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
This study aimed to establish a high-fat diet (HFD)-fed obese mouse model and a cell
culture model of insulin resistance (IR) in mature 3T3-L1 adipocytes. A dual-luciferase …
culture model of insulin resistance (IR) in mature 3T3-L1 adipocytes. A dual-luciferase …
The interplay among miRNAs, major cytokines, and cancer-related inflammation
Inflammation is closely related with the progression of cancer and is an indispensable
component that orchestrates the tumor microenvironment. Studies suggest that different …
component that orchestrates the tumor microenvironment. Studies suggest that different …
MicroRNAs; their therapeutic and biomarker properties
MicroRNAs (miRNAs) are, small (roughly 19–25 nucleotides in length), conserved, non-
coding, single-stranded, and functional RNA molecules with the properties of gene …
coding, single-stranded, and functional RNA molecules with the properties of gene …
[HTML][HTML] Change in circulating microRNA profile of obese children indicates future risk of adult diabetes
X Cui, L You, L Zhu, X Wang, Y Zhou, Y Li, J Wen… - Metabolism, 2018 - Elsevier
Purpose Childhood obesity increases susceptibility to type 2 diabetes (T2D) in adults.
Circulating microRNAs (miRNAs) in serum have been proposed as potential diagnostic …
Circulating microRNAs (miRNAs) in serum have been proposed as potential diagnostic …