Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Background miRNAs, a class of small endogenous RNAs, are one of the essential
biopharmaceuticals which are in commercial spans as next-generation medicine in recent …

Cognitive dysfunctions such as mild cognitive impairment (MCI), Alzheimer's disease (AD),
and other forms of dementia are recognized as common comorbidities of type 2 diabetes …

Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …

Diabetes is the most common metabolic disorder, with an extremely serious effect on health
systems worldwide. It has become a severe, chronic, non-communicable disease after …

Background The intestinal epithelial barrier is the interface for interaction between gut
microbiota and host metabolic systems. Akkermansia muciniphila (A. muciniphila) is a key …

Nanoscale small extracellular vesicles (sEVs, exosomes) in tears allow us to investigate the
multisignatures of diseases. However, the translations of tear sEVs for biomarker discovery …

This study aimed to establish a high-fat diet (HFD)-fed obese mouse model and a cell
culture model of insulin resistance (IR) in mature 3T3-L1 adipocytes. A dual-luciferase …

Purpose Childhood obesity increases susceptibility to type 2 diabetes (T2D) in adults.
Circulating microRNAs (miRNAs) in serum have been proposed as potential diagnostic …

Inflammation is closely related with the progression of cancer and is an indispensable
component that orchestrates the tumor microenvironment. Studies suggest that different …