Trained immunity: adaptation within innate immune mechanisms
J Domínguez-Andrés, JC Dos Santos… - Physiological …, 2023 - journals.physiology.org
The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …
last decades but are in fact largely unknown. Although the specificity of adaptive immune …
Natural killer cells: from innate to adaptive features
AM Mujal, RB Delconte, JC Sun - Annual review of immunology, 2021 - annualreviews.org
Natural killer (NK) cells are innate lymphocytes that provide critical host defense against
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …
[HTML][HTML] Prevention of tuberculosis in macaques after intravenous BCG immunization
Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide.
The only available vaccine, BCG (Bacillus Calmette–Guérin), is given intradermally and has …
The only available vaccine, BCG (Bacillus Calmette–Guérin), is given intradermally and has …
The immune landscape in tuberculosis reveals populations linked to disease and latency
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) latently infects
approximately one-fourth of the world's population. The immune mechanisms that govern …
approximately one-fourth of the world's population. The immune mechanisms that govern …
Airway T cells are a correlate of iv Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques
Summary Bacille Calmette-Guerin (BCG), the only approved Mycobacterium tuberculosis
(Mtb) vaccine, provides limited durable protection when administered intradermally …
(Mtb) vaccine, provides limited durable protection when administered intradermally …
Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung
E Moreo, A Jarit-Cabanillas, I Robles-Vera… - Nature …, 2023 - nature.com
Abstract Intravesical administration of Bacillus Calmette-Guérin (BCG) was one of the first
FDA-approved immunotherapies and remains a standard treatment for bladder cancer …
FDA-approved immunotherapies and remains a standard treatment for bladder cancer …
Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis
Multiple studies have broadened the roles of natural killer (NK) cells functioning as purely
innate lymphocytes by demonstrating that they are capable of putative antigen-specific …
innate lymphocytes by demonstrating that they are capable of putative antigen-specific …
Therapeutic vaccines for tuberculosis: an overview
R Bouzeyen, B Javid - Frontiers in Immunology, 2022 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis is the world's deadliest bacterial
infection, resulting in more than 1.4 million deaths annually. The emergence of drug …
infection, resulting in more than 1.4 million deaths annually. The emergence of drug …
[HTML][HTML] Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes
B Zhang, SJ Moorlag… - The Journal of …, 2022 - Am Soc Clin Investig
JCI - Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in
human monocytes Go to JCI Insight About Editors Consulting Editors For authors …
human monocytes Go to JCI Insight About Editors Consulting Editors For authors …
Trained immunity: an ancient way of remembering
MG Netea, JWM van der Meer - Cell host & microbe, 2017 - cell.com
The innate arm of the immune system has generally been regarded as primitive and non-
specific and, in contrast to adaptive immunity, not to possess memory. Here we review the …
specific and, in contrast to adaptive immunity, not to possess memory. Here we review the …