During the last two decades, DNA-based molecular markers have been extensively utilized
for a variety of studies in both plant and animal systems. One of the major uses of these …

Assessing the association between DNA variants and disease has been used widely to
identify regions of the genome and candidate genes that contribute to disease. However …

Geneticists have repeatedly turned to population isolates for map** and cloning
Mendelian disease genes. Population isolates possess many advantages in this regard …

During the past two decades, linkage analysis has been phenomenally successful in
localizing Mendelian disease genes. Linkage disequilibrium (LD) analysis, which effectively …

DNA sequence variants in specific genes or regions of the human genome are responsible
for a variety of phenotypes such as disease risk or variable drug response. These variants …

Haplotypes have played a major role in the study of highly‐penetrant single‐gene disorders,
and recent evidence that the human genome has hot‐spots and cold‐spots for …

On the causal hypothesis, most genetic determinants of disease are single-nucleotide
polymorphisms (SNPs) that are likely to be selected as markers for positional cloning. On the …

Allelic association methods are better suited than linkage analysis for map** of
susceptibility genes that confer modest increases in risk in complex diseases. In both family …

Linkage disequilibrium analysis can provide high resolution in the map** of disease
genes because it incorporates information on recombinations that have occurred during the …

Family-based procedures such as the transmission disequilibrium test (TDT) were motivated
by concern that sample-based methods to map disease genes by allelic association are not …