Neuroinflammation in Alzheimer disease

MT Heneka, WM van der Flier, F Jessen… - Nature Reviews …, 2024 - nature.com
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - Signal transduction and …, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Clinical trials of new drugs for Alzheimer disease: A 2020–2023 update

LK Huang, YC Kuan, HW Lin, CJ Hu - Journal of biomedical science, 2023 - Springer
Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet
medical need worldwide. The pathogenesis of AD involves various pathophysiological …

Tau-targeting therapies for Alzheimer disease: current status and future directions

EE Congdon, C Ji, AM Tetlow, Y Jiang… - Nature Reviews …, 2023 - nature.com
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

The effects of microglia-associated neuroinflammation on Alzheimer's disease

C Wang, S Zong, X Cui, X Wang, S Wu… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is defined as a severe chronic degenerative neurological disease
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …

Microglia phenotypes in aging and neurodegenerative diseases

MY Wendimu, SB Hooks - Cells, 2022 - mdpi.com
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease

D Bairamian, S Sha, N Rolhion, H Sokol… - Molecular …, 2022 - Springer
Background The implication of gut microbiota in the control of brain functions in health and
disease is a novel, currently emerging concept. Accumulating data suggest that the gut …

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

F Leng, P Edison - Nature Reviews Neurology, 2021 - nature.com
Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

[HTML][HTML] Microglia and Alzheimer's disease

S Merighi, M Nigro, A Travagli, S Gessi - International journal of molecular …, 2022 - mdpi.com
There is a huge need for novel therapeutic and preventative approaches to Alzheimer's
disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The …