G protein–coupled receptors (GPCRs) are a superfamily of transmembrane signal
transducers that facilitate the flow of chemical signals across membranes. GPCRs are a …

Introduction Bioluminescence is a well-established optical detection technique widely used
in several bioanalytical applications, including high-throughput and high-content …

G protein-coupled receptors (GPCRs) serve critical physiological roles as the most abundant
family of receptors. Here, we describe the design of a generalizable and cell lysate-based …

G protein‐coupled receptors (GPCRs) represent∼ 30% of current drug targets. Ligand
binding to these receptors activates G proteins and arrestins, which function in different …

The recent coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has spurred intense research efforts to …

Botulinum neurotoxins (BoNTs) have been widely used clinically as a muscle relaxant.
These toxins target motor neurons and cleave proteins essential for neurotransmitter release …

Recent advances in drug discovery have established biosensors as indispensable tools,
particularly valued for their precision, sensitivity, and real-time monitoring capabilities. The …

Serotonergic psychedelics induce altered states of consciousness and have shown potential
in treating a variety of neuropsychiatric disorders, including depression and addiction. Yet …

Translocations involving FGFR2 gene fusions are common in cholangiocarcinoma and
predict response to FGFR kinase inhibitors. However, the rate and durability of response are …

The quest for effective cancer treatments has driven transformative strategies in drug
discovery, and biosensors have emerged as indispensable tools, renowned for their …