The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

Asymmetric catalytic multicomponent cascade reactions have become indispensable tools
for enantioselective construction of spirooxindoles. In recent years, a number of successful …

Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …

Chiral spirooxindoles are privileged heterocyclic motifs, which are widely found in natural
alkaloids and pharmaceuticals. Moreover, the construction of chiral spiro-cyclic frameworks …

Indazole-containing derivatives represent one of the most important heterocycles in drug
molecules. Diversely substituted indazole derivatives bear a variety of functional groups and …

Diverse functionalized dihydrobenzofuran spiro-indanedione-oxindole scaffolds were
conveniently synthesized by base-promoted cyclization reaction of Morita–Baylis–Hillman …

We have developed an efficient protocol for the construction of polycyclic dihydrobenzofuran
spirooxindole scaffolds via base promoted cascade annulation of Morita–Baylis–Hillman …

A series of new spirooxindole-derived morpholine-fused-1, 2, 3-triazole derivatives has
been synthesized from isatin spiro-epoxides. The protocol involves regiospecific isatin …

The utility of natural products for identifying anticancer agents has been highly pursued in
the last decades and over 100 drug molecules in clinic are natural products or natural …

Background: Antibiotic resistance is one of the biggest threats to global health today, leading
to higher medical costs and increased mortality. Because of the emergence and rapid …