Abstract 30 years after the identification of WNTs, their signal transduction has become
increasingly complex, with the discovery of more than 15 receptors and co-receptors in …

Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation,
proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many …

Cancer is one of the greatest public health challenges. According to the World Health
Organization (WHO), 9.6 million cancer deaths have been reported in 2018. The most …

Wnt signaling is crucial for embryonic development in all animal species studied to date. The
interaction between Wnt proteins and cell surface receptors can result in a variety of …

Wnt ligands signal through β-catenin and are critically involved in cell fate determination and
stem/progenitor self-renewal. Wnts also signal through β-catenin-independent or …

The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral
fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced …

Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is
overexpressed in many types of malignant tumors. Studies have demonstrated that it plays …

Evolutionarily conserved receptor tyrosine kinase–like orphan receptor-1 and-2 (ROR1/2)
are considered distinct receptors for Wnt5a and are implicated in noncanonical Wnt …

Wnts compromise a large family of secreted, hydrophobic glycoproteins that control a variety
of developmental and adult processes in all metazoan organisms. Recent advances in the …

Wnt signaling determines major developmental processes in the embryonic state and
regulates maintenance, self-renewal and differentiation of adult mammalian tissue stem …