The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Somlyo, Andrew P., and Avril V. Somlyo. Ca2+ Sensitivity of Smooth Muscle and Nonmuscle
Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase. Physiol Rev 83 …

The blood–brain barrier (BBB) is a dynamic and complex interface between blood and the
central nervous system that strictly controls the exchanges between the blood and brain …

The endothelial cell (EC) lining of the pulmonary vasculature forms a semipermeable barrier
between the blood and the interstitium of the lung. Disruption of this barrier occurs during …

Reactive oxygen species (ROS) are generated at sites of inflammation and injury, and at low
levels, ROS can function as signaling molecules participating as signaling intermediates in …

Cortactin fulfills many functions in various cell types. These functions have been considered
to derive from its ability to activate the Actin-related protein 2/3 (Arp2/3) complex, and are …

Cell signaling events that lead to increased [Ca2+] i 1 in smooth and skeletal muscles
activate Ca2+/calmodulin-dependent MLCK. The kinase phosphorylates a specific site on …

Endothelial cells (ECs) actively regulate the extravasation of blood constituents. On
stimulation by vasoactive agents and thrombin, ECs change their cytoskeletal architecture …

Endothelium forms a semi-permeable barrier that separates blood from the underlying
tissue. Barrier function is largely determined by cell-cell and cell-matrix adhesions that …

Increased endothelial cell (EC) permeability is central to the pathophysiology of
inflammatory syndromes such as sepsis and acute lung injury (ALI). Activated protein C …