Molecular dynamics simulation in drug discovery: opportunities and challenges
Drug discovery is the process used to discover new candidate medications. In the past, most
drugs were discovered by identification of active-ingredients or by serendipity. Modern drug …
drugs were discovered by identification of active-ingredients or by serendipity. Modern drug …
Exploring Leishmania secretory proteins to design B and T cell multi-epitope subunit vaccine using immunoinformatics approach
Visceral leishmaniasis (VL) is a fatal form of leishmaniasis which affects 70 countries,
worldwide. Increasing drug resistance, HIV co-infection, and poor health system require …
worldwide. Increasing drug resistance, HIV co-infection, and poor health system require …
Molecular dynamics simulation of protein and protein–ligand complexes
Biomacromolecules, including proteins and their complexes, adopt multiple conformations
that are linked to their biological functions. Though some of the structural heterogeneity can …
that are linked to their biological functions. Though some of the structural heterogeneity can …
Virtual screening of natural products database
JA de Sousa Luis, RPC Barros… - Mini Reviews in …, 2021 - ingentaconnect.com
Constant research on natural products has generated, over time, a large number of
compounds with the potential to be evaluated in several biological tests and subsequently …
compounds with the potential to be evaluated in several biological tests and subsequently …
Golgi Apparatus-Targeted Photodynamic Therapy for Enhancing Tumor Immunogenicity by Eliciting NLRP3 Protein-Dependent Pyroptosis
ZC Hu, B Wang, XG Zhou, HF Liang, B Liang, HW Lu… - ACS …, 2023 - ACS Publications
Innate and adaptive immunity is important for initiating and maintaining immune function.
The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing …
The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing …
Well-dispersed platelet lysate entrapped nanoparticles incorporate with injectable PDLLA-PEG-PDLLA triblock for preferable cartilage engineering application
Q Tang, T Lim, LY Shen, G Zheng, XJ Wei, CQ Zhang… - Biomaterials, 2021 - Elsevier
Platelet lysate (PL) as a cost-effective cocktail of growth factors is an emerging ingredient in
regenerative medicine, especially in cartilage tissue engineering. However, most studies fail …
regenerative medicine, especially in cartilage tissue engineering. However, most studies fail …
In-silico anti-inflammatory potential of guaiane dimers from Xylopia vielana targeting COX-2
Natural products of herbal origin are prodigious to display diverse pharmacological
activities. In the present study, five guaiane-type sesquiterpene dimers, xylopidimers A− E (1 …
activities. In the present study, five guaiane-type sesquiterpene dimers, xylopidimers A− E (1 …
Designing B‐and T‐cell multi‐epitope based subunit vaccine using immunoinformatics approach to control Zika virus infection
The Zika virus is a rapidly spreading Aedes mosquito‐borne sickness, which creates an
unanticipated linkage birth deformity and neurological turmoil. This study represents the use …
unanticipated linkage birth deformity and neurological turmoil. This study represents the use …
Epigallocatechin gallate, an active green tea compound inhibits the Zika virus entry into host cells via binding the envelope protein
Emerging infections of Zika virus (ZIKV) are associated with serious consequences like
microcephaly and Guillain-Barré syndrome. It leads to a situation of global health …
microcephaly and Guillain-Barré syndrome. It leads to a situation of global health …
Strategic development of a next-generation multi-epitope vaccine to prevent Nipah virus zoonotic infection
Nipah virus (NiV) is an emerging zoonotic pathogen, reported for the recent severe
outbreaks of encephalitis and respiratory illness in humans and animals, respectively. Many …
outbreaks of encephalitis and respiratory illness in humans and animals, respectively. Many …