Chemotaxis, the directed migration of cells in chemical gradients, is a vital process in normal
physiology and in the pathogenesis of many diseases. Chemotactic cells display motility …

Dictyostelia are soil amoebae capable of extraordinary feats of survival, motility, chemotaxis,
and development. Characterised by their ability to transform from a single-celled organism …

Serotonergic dysregulation within the prefrontal cortex (PFC) is implicated in many
neuropsychiatric disorders, but the precise role of serotonin within the PFC is poorly …

In nature, microorganisms must often cope with hostile environmental conditions. To do so
they have developed sophisticated cooperative behaviour and intricate communication …

Cells grow, move, expand, shrink and die in the process of generating the characteristic
shapes of organisms. Although the structures generated during development of the social …

When individual amoebae of the cellular slime mold Dictyostelium discoideum are starving,
they aggregate to form a multicellular migrating slug, which moves toward a region suitable …

A" brain defibrillator" may be closer than we think. An epileptic seizure involves a
paroxysmal change in the activity of millions of neurons. Feedback control of seizures would …

We present results of experiments on the dynamics of Dictyostelium discoideum in a novel
setup which constrains cell motion to a plane. After aggregation, the amoebae collect into …

Akt is a protein serine/threonine kinase that plays an important role in the mitogenic
responses of cells to variable stimuli. Akt contains a pleckstrin homology (PH) domain and is …

Self-regulating systems often use robust oscillatory circuits. One such system controls the
chemotactic signaling mechanism of Dictyostelium, where pulses of adenosine 3′, 5 …