The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …

The modification of proteins with ubiquitin chains can change their localization, activity
and/or stability. Although ubiquitylation requires the concerted action of ubiquitin-activating …

Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the
haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon …

Context Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian
cancer have produced conflicting results. Objective To determine the relationships between …

Many cancer-associated genes remain to be identified to clarify the underlying molecular
mechanisms of cancer susceptibility and progression. Better understanding is also required …

Solid tumors can be highly aneuploid and many display high rates of chromosome
missegregation in a phenomenon called chromosomal instability (CIN). In principle …

Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To
identify pathways supporting the Myc oncogenic program, we used a genome-wide RNA …

Expression of receptor for hyaluronan-mediated motility (RHAMM), a breast cancer
susceptibility gene, is tightly controlled in normal tissues but elevated in many tumors …

Germline mutations in BRCA1 and BRCA2 predispose to common human malignancies,
most notably tumors of the breast and ovaries. The proteins encoded by these genes have …

Most solid tumours are aneuploid and many frequently mis-segregate chromosomes. This
chromosomal instability is commonly caused by persistent mal-oriented attachment of …