Developmental gene expression is often controlled by distal regulatory DNA elements called
enhancers. Distant enhancer action is restricted to structural chromosomal domains that are …

Additional sex combs like 1 (ASXL1) is frequently mutated in myeloid malignancies and
clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes …

In the eukaryotic nucleus, genes are transcribed in transcription factories. In the present
review, we re-evaluate the models of transcription factories in the light of recent and older …

The histone acetyltransferases (HATs) of the MYST family include TIP60, HBO1,
MOZ/MORF, and MOF and function in multisubunit protein complexes. Bromodomain …

Erythropoiesis is the process by which progenitors for red blood cells are produced and
terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages …

Suppressor of cytokine signaling 3 (SOCS3) down-regulates several signaling pathways in
multiple cell types, and previous data suggest that SOCS3 may shut off cytokine activation at …

The AP-1 transcription factor (TF) dimer contributes to many biological processes and
environmental responses. AP-1 can be composed of many interchangeable subunits …

Understanding the pattern of gene expression during erythropoiesis is crucial for a synthesis
of erythroid developmental biology. Here, we isolated 4 distinct populations at successive …

Background Mammalian-wide interspersed repeats (MIRs) are the most ancient family of
transposable elements (TEs) in the human genome. The deep conservation of MIRs initially …

An effective utilization of intracellular iron is a prerequisite for erythroid differentiation and
hemoglobinization. Ferritin, consisting of 24 subunits of H and L, plays a crucial role in iron …