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A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …
Computational approaches for modeling and structural design of biological systems: A comprehensive review
E Gayathiri, P Prakash, P Kumaravel… - Progress in Biophysics …, 2023 - Elsevier
The convergence of biology and computational science has ushered in a revolutionary era,
revolutionizing our understanding of biological systems and providing novel solutions to …
revolutionizing our understanding of biological systems and providing novel solutions to …
Multimodal transformers and their applications in drug target discovery for aging and age-related diseases
B Steurer, Q Vanhaelen… - The Journals of …, 2024 - academic.oup.com
Given the unprecedented rate of global aging, advancing aging research and drug
discovery to support healthy and productive longevity is a pressing socioeconomic need …
discovery to support healthy and productive longevity is a pressing socioeconomic need …
nach0: Multimodal natural and chemical languages foundation model
Large Language Models (LLMs) have substantially driven scientific progress in various
domains, and many papers have demonstrated their ability to tackle complex problems with …
domains, and many papers have demonstrated their ability to tackle complex problems with …
The role of artificial intelligence in drug screening, drug design, and clinical trials
Y Wu, L Ma, X Li, J Yang, X Rao, Y Hu, J **… - Frontiers in …, 2024 - frontiersin.org
The role of computational tools in drug discovery and development is becoming increasingly
important due to the rapid development of computing power and advancements in …
important due to the rapid development of computing power and advancements in …
Increasing acceptance of AI‐generated digital twins through clinical trial applications
AA Vidovszky, CK Fisher, AD Loukianov… - Clinical and …, 2024 - Wiley Online Library
Today's approach to medicine requires extensive trial and error to determine the proper
treatment path for each patient. While many fields have benefited from technological …
treatment path for each patient. While many fields have benefited from technological …
Artificial intelligence in drug development
Drug development is a complex and time-consuming endeavor that traditionally relies on the
experience of drug developers and trial-and-error experimentation. The advent of artificial …
experience of drug developers and trial-and-error experimentation. The advent of artificial …
Integrating clinical pharmacology and artificial intelligence: potential benefits, challenges, and role of clinical pharmacologists
H Singh, DK Nim, AS Randhawa… - Expert Review of …, 2024 - Taylor & Francis
Introduction The integration of artificial intelligence (AI) into clinical pharmacology could be a
potential approach for accelerating drug discovery and development, improving patient care …
potential approach for accelerating drug discovery and development, improving patient care …
Emerging pharmacological options in the treatment of idiopathic pulmonary fibrosis (IPF)
K Aribindi, GY Liu, TE Albertson - Expert Review of Clinical …, 2024 - Taylor & Francis
Introduction Idiopathic pulmonary fibrosis (IPF) is a progressive-fibrosing lung disease with a
median survival of less than 5 years. Currently, two agents, pirfenidone and nintedanib are …
median survival of less than 5 years. Currently, two agents, pirfenidone and nintedanib are …