A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models

F Ren, A Aliper, J Chen, H Zhao, S Rao, C Kuppe… - Nature …, 2024 - nature.com
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …

Computational approaches for modeling and structural design of biological systems: A comprehensive review

E Gayathiri, P Prakash, P Kumaravel… - Progress in Biophysics …, 2023 - Elsevier
The convergence of biology and computational science has ushered in a revolutionary era,
revolutionizing our understanding of biological systems and providing novel solutions to …

Multimodal transformers and their applications in drug target discovery for aging and age-related diseases

B Steurer, Q Vanhaelen… - The Journals of …, 2024 - academic.oup.com
Given the unprecedented rate of global aging, advancing aging research and drug
discovery to support healthy and productive longevity is a pressing socioeconomic need …

nach0: Multimodal natural and chemical languages foundation model

M Livne, Z Miftahutdinov, E Tutubalina… - Chemical …, 2024 - pubs.rsc.org
Large Language Models (LLMs) have substantially driven scientific progress in various
domains, and many papers have demonstrated their ability to tackle complex problems with …

The role of artificial intelligence in drug screening, drug design, and clinical trials

Y Wu, L Ma, X Li, J Yang, X Rao, Y Hu, J **… - Frontiers in …, 2024 - frontiersin.org
The role of computational tools in drug discovery and development is becoming increasingly
important due to the rapid development of computing power and advancements in …

Increasing acceptance of AI‐generated digital twins through clinical trial applications

AA Vidovszky, CK Fisher, AD Loukianov… - Clinical and …, 2024 - Wiley Online Library
Today's approach to medicine requires extensive trial and error to determine the proper
treatment path for each patient. While many fields have benefited from technological …

Artificial intelligence in drug development

K Zhang, X Yang, Y Wang, Y Yu, N Huang, G Li, X Li… - Nature Medicine, 2025 - nature.com
Drug development is a complex and time-consuming endeavor that traditionally relies on the
experience of drug developers and trial-and-error experimentation. The advent of artificial …

Integrating clinical pharmacology and artificial intelligence: potential benefits, challenges, and role of clinical pharmacologists

H Singh, DK Nim, AS Randhawa… - Expert Review of …, 2024 - Taylor & Francis
Introduction The integration of artificial intelligence (AI) into clinical pharmacology could be a
potential approach for accelerating drug discovery and development, improving patient care …

Emerging pharmacological options in the treatment of idiopathic pulmonary fibrosis (IPF)

K Aribindi, GY Liu, TE Albertson - Expert Review of Clinical …, 2024 - Taylor & Francis
Introduction Idiopathic pulmonary fibrosis (IPF) is a progressive-fibrosing lung disease with a
median survival of less than 5 years. Currently, two agents, pirfenidone and nintedanib are …