The versatility of mitochondrial metabolism and its fine adjustments to specific physiological
or pathological conditions regulate fundamental cell pathways, ranging from proliferation to …

The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria …

Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

During the past two decades calcium (Ca2+) accumulation in energized mitochondria has
emerged as a biological process of utmost physiological relevance. Mitochondrial Ca2+ …

Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …

The Bcl-2 family of proteins controls a critical step in commitment to apoptosis by regulating
permeabilization of the mitochondrial outer membrane (MOM). The family is divided into …

In the last decade, the endoplasmic reticulum (ER) has emerged as a central organelle
regulating the core mitochondrial apoptosis pathway. At the ER membrane, a variety of …

Mitochondria are energy factories of cells and are important pivots for intracellular
interactions with other organelles. They interact with the endoplasmic reticulum …

Summary B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of
proteins, which were originally characterized with respect to their roles in controlling outer …

Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by
releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish …