Nanoparticle-based medicines in clinical cancer therapy

S Wang, K Cheng, K Chen, C Xu, P Ma, G Dang… - Nano Today, 2022 - Elsevier
Anti-cancer drugs with various mechanisms emerge in succession, but most of free
therapeutics are accompanied by some disadvantages, such as poor safety and …

PLGA-based nanomedicine: history of advancement and development in clinical applications of multiple diseases

HO Alsaab, FD Alharbi, AS Alhibs, NB Alanazi… - Pharmaceutics, 2022 - mdpi.com
Research on the use of biodegradable polymers for drug delivery has been ongoing since
they were first used as bioresorbable surgical devices in the 1980s. For tissue engineering …

Exploring the current landscape of chitosan-based hybrid nanoplatforms as cancer theragnostic

R Nair, P Paul, I Maji, U Gupta, S Mahajan… - Carbohydrate …, 2024 - Elsevier
In the last decade, investigators have put significant efforts to develop several diagnostic
and therapeutic strategies against cancer. Many novel nanoplatforms, including lipidic …

Current perspectives on taxanes: Focus on their bioactivity, delivery and combination therapy

J Škubník, V Pavlíčková, T Ruml, S Rimpelová - Plants, 2021 - mdpi.com
Taxanes, mainly paclitaxel and docetaxel, the microtubule stabilizers, have been well known
for being the first-line therapy for breast cancer for more than the last thirty years. Moreover …

PLGA's plight and the role of stealth surface modification strategies in its use for intravenous particulate drug delivery

VV Sheffey, EB Siew, EEL Tanner… - Advanced …, 2022 - Wiley Online Library
Numerous human disorders can benefit from targeted, intravenous (IV) drug delivery.
Polymeric nanoparticles have been designed to undergo systemic circulation and deliver …

Recent advances in PLGA based nanocarriers for drug delivery system: a state of the art review

SR Pardeshi, A Nikam, P Chandak… - … Journal of Polymeric …, 2023 - Taylor & Francis
The biomolecules in the clinical use being delivered by the conventional mode of delivery
often exhibit poor affinity. So, there is a need for a nanomedicine-based approach that could …

Paclitaxel drug delivery systems: Focus on nanocrystals' surface modifications

R Haddad, N Alrabadi, B Altaani, T Li - Polymers, 2022 - mdpi.com
Paclitaxel (PTX) is a chemotherapeutic agent that belongs to the taxane family and which
was approved to treat various kinds of cancers including breast cancer, ovarian cancer …

Lipid poly (ɛ-caprolactone) hybrid nanoparticles of 5-fluorouracil for sustained release and enhanced anticancer efficacy

S Khan, MN Aamir, A Madni, N Jan, A Khan, A Jabar… - Life Sciences, 2021 - Elsevier
Aims The present study aimed to develop and characterize poly (ɛ-caprolactone)(PCL)
based lipid polymer hybrid nanoparticles for sustained delivery and in-vitro anti-cancer …

Lipid-based nanoparticles in delivering bioactive compounds for improving therapeutic efficacy

P Patel, K Garala, S Singh, BG Prajapati… - Pharmaceuticals, 2024 - mdpi.com
In recent years, due to their distinctive and adaptable therapeutic effects, many natural
bioactive compounds have been commonly used to treat diseases. Their limited solubility …

Development of sustained release baricitinib loaded lipid-polymer hybrid nanoparticles with improved oral bioavailability

MK Anwer, EA Ali, M Iqbal, MM Ahmed, MF Aldawsari… - Molecules, 2021 - mdpi.com
Baricitinib (BTB) is an orally administered Janus kinase inhibitor, therapeutically used for the
treatment of rheumatoid arthritis. Recently it has also been approved for the treatment of …