Much of what is currently known concerning microtubule biochemistry and physiology has
come from studies of the interaction of various plant alkaloids with microtubules. This …

An overwhelming amount of data has imphcated the cell surface as the primary s~ te for
control of cell growth, dwlslon, development, commumcatlon, differentiation and death. Cells …

A heat stable protein essentail for microtubule assembly has been isolated. This protein,
which we designate tau (tau), is present in association with tubulin purified from porcine …

Taxol, a potent inhibitor of human HeLa and mouse fibroblast cell replication, blocked cells
in the G2 and M phase of the cell cycle and stabilized cytoplasmic microtubules. The …

Cell Movements vividly describes how complex movements can arise from the properties
and behaviors of biological molecules. This second edition is updated throughout with …

The major protein of intermediate-sized filaments in mouse 3T3 cells, for which the name
vimentin is proposed, has a molecular weight of 57,000. Antibodies against vimentin and …

Hibernating mammals survive hypothermia (< 10° C) without injury, a remarkable feat of
cellular preservation that bears significance for potential medical applications. However …

Electron microscopy and indirect immunofluorescence microscopy using monospecific
tubulin antibodies were performed in parallel on glutaraldehyde-fixed tissue culture cells …

Some 18 years ago, tubulin was originally identified as the soluble protein found in most
eukaryotic cells that tightly bound the antimitotic drug colchicine (1, 2). Quickly thereafter …

A method is described by which HeLa cells can be fractionated to reveal a skeletal-like
structure in the cytoplasm. This cytoskeleton has many of the cell's ultrastructural features …