The Morris water maze (MWM) was described 20 years ago as a device to investigate
spatial learning and memory in laboratory rats. In the meanwhile, it has become one of the …

In Alzheimer's disease (AD) basic research and drug discovery, mouse models are essential
resources for uncovering biological mechanisms, validating molecular targets and screening …

Thousands of infants and children undergo complicated surgical procedures that require
prolonged periods of anesthesia and/or sedation each year. A growing body of preclinical …

Environmental enrichment induces structural and biochemical changes in the brains of
mammals that correlate with improved learning and memory. Research in rats suggests that …

The involvement of the medial prefrontal cortex (mPFC), and more particularly the prelimbic
and infralimbic cortices (PL-IL area), in spatial memory remains controversial. The present …

The question examined in this study is concerned with a possible functional dissociation
between the hippocampal formation and the prefrontal cortex in spatial navigation. Wistar …

Alzheimer's disease (AD) is a neurodegenerative disorder and most common form of
dementia that leads to memory impairment. In the present study we have examined the …

Chronic cerebral hypoperfusion (CCH) is a cardinal risk factor for Parkinson's disease
dementia (PDD), but this potential causality lacks mechanistic evidence. We selected …

The anterior and laterodorsal thalamic nuclei provide massive projections to the anterior
cingulate and frontal cortices in the rat. However, the organization of reciprocal …

This study investigates the implication of the hippocampal CA3-region in the different
phases of learning and memory in spatial and non-spatial tasks. For that purpose, we …