Molecular mechanisms underlying neurotransmitter release
J Rizo - Annual Review of Biophysics, 2022 - annualreviews.org
Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …
Chaperoning SNARE folding and assembly
Y Zhang, FM Hughson - Annual review of biochemistry, 2021 - annualreviews.org
SNARE proteins and Sec1/Munc18 (SM) proteins constitute the core molecular engine that
drives nearly all intracellular membrane fusion and exocytosis. While SNAREs are known to …
drives nearly all intracellular membrane fusion and exocytosis. While SNAREs are known to …
SNARE assembly enlightened by cryo-EM structures of a synaptobrevin–Munc18-1–syntaxin-1 complex
Munc18-1 forms a template to organize assembly of the neuronal SNARE complex that
triggers neurotransmitter release, binding first to a closed conformation of syntaxin-1 where …
triggers neurotransmitter release, binding first to a closed conformation of syntaxin-1 where …
All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer
Synaptic vesicles are primed into a state that is ready for fast neurotransmitter release upon
Ca 2+-binding to Synaptotagmin-1. This state likely includes trans-SNARE complexes …
Ca 2+-binding to Synaptotagmin-1. This state likely includes trans-SNARE complexes …
Mechanism of neurotransmitter release coming into focus
J Rizo - Protein Science, 2018 - Wiley Online Library
Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …
Dynamically primed synaptic vesicle states: key to understand synaptic short-term plasticity
E Neher, N Brose - Neuron, 2018 - cell.com
Based on evidence that the docked and primed synaptic vesicle state is very dynamic, we
propose a three-step process for the buildup of the molecular machinery that mediates …
propose a three-step process for the buildup of the molecular machinery that mediates …
The machinery of vesicle fusion
AE Stanton, FM Hughson - Current Opinion in Cell Biology, 2023 - Elsevier
The compartmentalization of eukaryotic cells is reliant on the fidelity of vesicle-mediated
intracellular transport. Vesicles deliver their cargo via membrane fusion, a process requiring …
intracellular transport. Vesicles deliver their cargo via membrane fusion, a process requiring …
Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association
Sec1/Munc18-family (SM) proteins are required for SNARE-mediated membrane fusion, but
their mechanism (s) of action remain controversial. Using single-molecule force …
their mechanism (s) of action remain controversial. Using single-molecule force …
STXBP1 encephalopathies: clinical spectrum, disease mechanisms, and therapeutic strategies
D Abramov, NGL Guiberson… - Journal of …, 2021 - Wiley Online Library
Abstract Mutations in Munc18‐1/STXBP1 (syntaxin‐binding protein 1) are linked to various
severe early epileptic encephalopathies and neurodevelopmental disorders. Heterozygous …
severe early epileptic encephalopathies and neurodevelopmental disorders. Heterozygous …
Molecular mechanisms of fast neurotransmitter release
AT Brunger, UB Choi, Y Lai, J Leitz… - Annual review of …, 2018 - annualreviews.org
This review summarizes current knowledge of synaptic proteins that are central to synaptic
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …