Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Aging is a complex and multifaceted process involving a variety of interrelated molecular
mechanisms and cellular systems. Phenotypically, the biological aging process is …

Ageing is a complex biological process associated with increased morbidity and mortality.
Nine classic, interdependent hallmarks of ageing have been proposed involving genetic and …

Low-protein diets promote health and longevity in diverse species. Restriction of the
branched-chain amino acids (BCAAs) leucine, isoleucine, and valine recapitulates many of …

The mechanistic target of rapamycin complex 1 controls cellular anabolism in response to
growth factor signaling and to nutrient sufficiency signaled through the Rag GTPases …

Sarcopenia is a debilitating skeletal muscle disease that accelerates in the last decades of
life and is characterized by marked deficits in muscle strength, mass, quality, and metabolic …

Background As a result of aging, skeletal muscle undergoes atrophy and a decrease in
function. This age-related skeletal muscle weakness is known as “sarcopenia”. Sarcopenia …

Sarcopenia is a progressive muscle wasting disorder that severely impacts the quality of life
of elderly individuals. Although the natural aging process primarily causes sarcopenia, it can …