Frailty: a multidimensional biopsychosocial syndrome

CI Cohen, R Benyaminov, MM Rahman… - Medical …, 2023 - medical.theclinics.com
Frailty is thought to be one of the most serious public health challenges of the twentyfirst
century. 1 All older adults are at risk for develo** frailty, and it is associated with many …

Impact of exercise training on physical and cognitive function among older adults: a systematic review and meta-analysis

RS Falck, JC Davis, JR Best, RA Crockett… - Neurobiology of …, 2019 - Elsevier
Exercise plays a key role in healthy aging by promoting both physical and cognitive function.
Physical function and cognitive function appear to be interrelated and may share common …

Comprehensive evaluation of the 5XFAD mouse model for preclinical testing applications: a MODEL-AD study

AL Oblak, PB Lin, KP Kotredes, RS Pandey… - Frontiers in aging …, 2021 - frontiersin.org
The ability to investigate therapeutic interventions in animal models of neurodegenerative
diseases depends on extensive characterization of the model (s) being used. There are …

Oral frailty indicators to target major adverse health-related outcomes in older age: a systematic review

V Dibello, F Lobbezoo, M Lozupone, R Sardone… - Geroscience, 2023 - Springer
A well-preserved oral function is key to accomplishing essential daily tasks. However, in
geriatric medicine and gerodontology, as age-related physiological decline disrupts several …

An update on cognitive frailty: Its definition, impact, associated factors and underlying mechanisms, and interventions

T Sugimoto, H Arai, T Sakurai - Geriatrics & gerontology …, 2022 - Wiley Online Library
Since the concept and operational definition of “cognitive frailty”(simultaneous presence of
physical frailty and cognitive impairment without concurrent dementia) were proposed by the …

Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer's disease: a cross-sectional analysis of data from the …

LMK Wallace, O Theou, J Godin, MK Andrew… - The Lancet …, 2019 - thelancet.com
Background Some people with substantial Alzheimer's disease pathology at autopsy had
shown few characteristic clinical symptoms or signs of the disease, whereas others with little …

Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

A Ticinesi, C Tana, A Nouvenne, B Prati… - … interventions in aging, 2018 - Taylor & Francis
Cognitive frailty, defined as the coexistence of mild cognitive impairment symptoms and
physical frailty phenotype in older persons, is increasingly considered the main geriatric …

Cognitive frailty as a predictor of adverse outcomes among older adults: A systematic review and meta‐analysis

ZH Bu, AL Huang, MT Xue, QY Li, YM Bai… - Brain and …, 2021 - Wiley Online Library
Objective A systematic review and meta‐analysis basing on the prospective cohort studies
were conducted to explore the risk of all‐cause mortality and dementia in cognitively frail …

Bidirectional relationship between caregiver burden and neuropsychiatric symptoms in patients with Alzheimer's disease: a narrative review

AT Isik, P Soysal, M Solmi… - International journal of …, 2019 - Wiley Online Library
Objective The aim of this review is to make a state of the art of the potential influence of
neuropsychiatric symptoms (NPs) on caregiver stress and vice versa. Methods We searched …

Frailty as a predictor of cognitive disorders: a systematic review and meta-analysis

MK Borges, M Canevelli, M Cesari… - Frontiers in medicine, 2019 - frontiersin.org
Background/Aim: Current evidence in the literature supports associations between frailty,
cognitive impairment, and dementia. The study aim was to describe the risk of cognitive …