Shelterin-mediated telomere protection
T De Lange - Annual review of genetics, 2018 - annualreviews.org
For more than a decade, it has been known that mammalian cells use shelterin to protect
chromosome ends. Much progress has been made on the mechanism by which shelterin …
chromosome ends. Much progress has been made on the mechanism by which shelterin …
DNA replication origin activation in space and time
M Fragkos, O Ganier, P Coulombe… - Nature reviews Molecular …, 2015 - nature.com
DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …
How shelterin protects mammalian telomeres
W Palm, T de Lange - Annual review of genetics, 2008 - annualreviews.org
The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …
An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System
The fission yeast Schizosaccharomyces pombe is an important model organism for the study
of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its …
of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its …
Telomerase catalytic subunit homologs from fission yeast and human
Catalytic protein subunits of telomerase from the ciliate Euplotes aediculatus and the yeast
Saccharomyces cerevisiae contain reverse transcriptase motifs. Here the homologous …
Saccharomyces cerevisiae contain reverse transcriptase motifs. Here the homologous …
Finding the end: recruitment of telomerase to telomeres
Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …
The epigenetic regulation of mammalian telomeres
MA Blasco - Nature Reviews Genetics, 2007 - nature.com
Increasing evidence indicates that chromatin modifications are important regulators of
mammalian telomeres. Telomeres provide well studied paradigms of heterochromatin …
mammalian telomeres. Telomeres provide well studied paradigms of heterochromatin …
Protection of mammalian telomeres
T de Lange - Oncogene, 2002 - nature.com
Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When
telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA …
telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA …
Telomeres and telomerase
SRWL Chan, EH Blackburn - … Transactions of the …, 2004 - royalsocietypublishing.org
Telomeres are the protective DNA–protein complexes found at the ends of eukaryotic
chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G–rich …
chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G–rich …
Regulation of telomerase by telomeric proteins
A Smogorzewska, T de Lange - Annual review of biochemistry, 2004 - annualreviews.org
▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …
telomere functions and the associated chromosomal abnormalities have been implicated in …