Shelterin-mediated telomere protection

T De Lange - Annual review of genetics, 2018 - annualreviews.org
For more than a decade, it has been known that mammalian cells use shelterin to protect
chromosome ends. Much progress has been made on the mechanism by which shelterin …

DNA replication origin activation in space and time

M Fragkos, O Ganier, P Coulombe… - Nature reviews Molecular …, 2015 - nature.com
DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …

How shelterin protects mammalian telomeres

W Palm, T de Lange - Annual review of genetics, 2008 - annualreviews.org
The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System

CS Hoffman, V Wood, PA Fantes - Genetics, 2015 - academic.oup.com
The fission yeast Schizosaccharomyces pombe is an important model organism for the study
of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its …

Telomerase catalytic subunit homologs from fission yeast and human

TM Nakamura, GB Morin, KB Chapman, SL Weinrich… - Science, 1997 - science.org
Catalytic protein subunits of telomerase from the ciliate Euplotes aediculatus and the yeast
Saccharomyces cerevisiae contain reverse transcriptase motifs. Here the homologous …

Finding the end: recruitment of telomerase to telomeres

J Nandakumar, TR Cech - Nature reviews Molecular cell biology, 2013 - nature.com
Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

The epigenetic regulation of mammalian telomeres

MA Blasco - Nature Reviews Genetics, 2007 - nature.com
Increasing evidence indicates that chromatin modifications are important regulators of
mammalian telomeres. Telomeres provide well studied paradigms of heterochromatin …

Protection of mammalian telomeres

T de Lange - Oncogene, 2002 - nature.com
Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When
telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA …

Telomeres and telomerase

SRWL Chan, EH Blackburn - … Transactions of the …, 2004 - royalsocietypublishing.org
Telomeres are the protective DNA–protein complexes found at the ends of eukaryotic
chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G–rich …

Regulation of telomerase by telomeric proteins

A Smogorzewska, T de Lange - Annual review of biochemistry, 2004 - annualreviews.org
▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …