Streptomyces bacteria have been studied for more than 80 years thanks to their ability to
produce an incredible array of antibiotics and other specialized metabolites and their …

Chromosomes in all domains of life are well-defined structural entities with complex
hierarchical organization. The regulation of this hierarchical organization and its functional …

The soil-dwelling filamentous bacteria, Streptomyces, is widely known for its ability to
produce numerous bioactive natural products. Despite many efforts toward their …

Background Bacteria and their viruses, bacteriophages, are the most abundant entities of
the gut microbiota, a complex community of microorganisms associated with human health …

Bacterial species from diverse phyla contain multiple replicons, yet how these multipartite
genomes are organized and segregated during the cell cycle remains poorly understood …

Streptomyces are soil bacteria with complex life cycle. During sporulation Streptomyces
linear chromosomes become highly compacted so that the genetic material fits within limited …

The accurate distribution of genetic material is crucial for all organisms. In most bacteria,
chromosome segregation is achieved by the ParABS system, in which the ParB-bound parS …

Most biosynthetic gene clusters (BGC) encoding the synthesis of important microbial
secondary metabolites, such as antibiotics, are either silent or poorly expressed; therefore …

Bdellovibrio bacteriovorus, an obligate predatory Gram-negative bacterium that proliferates
inside and kills other Gram-negative bacteria, was discovered more than 60 years ago …

Bacterial chromosome topology is controlled by topoisomerases and nucleoid-associated
proteins (NAPs). While topoisomerases regulate DNA supercoiling, NAPs introduce bends …