Integrins are a family of transmembrane cell surface molecules that constitute the principal
adhesion receptors for the extracellular matrix (ECM) and are indispensable for the …

Integrins are a family of heterodimeric receptors that bind to components of the extracellular
matrix and influence cellular processes as varied as proliferation and migration. These …

Poor penetration of drugs into tumors is a major obstacle in tumor treatment. We describe a
strategy for peptide-mediated delivery of compounds deep into the tumor parenchyma that …

Vimentin is the major intermediate filament (IF) protein of mesenchymal cells. It shows
dynamically altered expression patterns during different developmental stages and high …

The use of antibody-drug conjugates (ADCs) as a therapeutic platform to treat cancer has
recently gained substantial momentum. This therapeutic modality has the potential to …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Since it has become clear that adhesion receptors are trafficked through the endosomal
pathway and that this can influence their function, much effort has been invested in obtaining …

Slender bundled actin containing plasma membrane protrusions, called filopodia, are
important for many essential cellular processes like cell adhesion, migration, angiogenesis …

Directional cell migration is a fundamental process required for embryonic development,
inflammation, wound healing, cancer metastasis, and atherosclerosis (Lauffenburger and …

Integrin adhesion receptors are essential for the normal function of most multicellular
organisms, and defective integrin activation or integrin signaling is associated with an array …