Pathogenesis and management of traumatic brain injury (TBI): role of neuroinflammation and anti-inflammatory drugs

S Kalra, R Malik, G Singh, S Bhatia, A Al-Harrasi… - …, 2022 - Springer
Traumatic brain injury (TBI) is an important global health concern that represents a leading
cause of death and disability. It occurs due to direct impact or hit on the head caused by …

A critical appraisal of tau‐targeting therapies for primary and secondary tauopathies

BP Imbimbo, S Ippati, M Watling… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Primary tauopathies are neurological disorders in which tau protein deposition
is the predominant pathological feature. Alzheimer's disease is a secondary tauopathy with …

[HTML][HTML] In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by …

D Zhang, Y Ren, Y He, R Chang, S Guo, S Ma… - Materials Today Bio, 2022 - Elsevier
The efficacy of neural repair and regeneration strategies for traumatic brain injury (TBI)
treatment is greatly hampered by the harsh brain lesion microenvironment including …

Environmental toxins and Alzheimer's disease: a comprehensive analysis of pathogenic mechanisms and therapeutic modulation

R Dhapola, P Sharma, S Kumari, JS Bhatti… - Molecular …, 2024 - Springer
Alzheimer's disease is a leading cause of mortality worldwide. Inorganic and organic
hazards, susceptibility to harmful metals, pesticides, agrochemicals, and air pollution are …

New neurons in adult brain: distribution, molecular mechanisms and therapies

A Pino, G Fumagalli, F Bifari, I Decimo - Biochemical pharmacology, 2017 - Elsevier
Abstract “Are new neurons added in the adult mammalian brain?”“Do neural stem cells
activate following CNS diseases?”“How can we modulate their activation to promote …

[HTML][HTML] IKK2/NF-κB signaling protects neurons after traumatic brain injury

M Mettang, SN Reichel, M Lattke, A Palmer… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is the leading cause of death in young adults. After the initial
injury, a poorly understood secondary phase, including a strong inflammatory response …

Chronic traumatic encephalopathy: update on current clinical diagnosis and management

K Pierre, K Dyson, A Dagra, E Williams, K Porche… - Biomedicines, 2021 - mdpi.com
Chronic traumatic encephalopathy is a disease afflicting individuals exposed to repetitive
neurotrauma. Unfortunately, diagnosis is made by postmortem pathologic analysis, and …

Protective effects of hinokitiol on neuronal ferroptosis by activating the Keap1/Nrf2/HO-1 pathway in traumatic brain injury

H Tang, K He, K Zhao, C Zheng, W Wu, W **… - Journal of …, 2024 - liebertpub.com
In this study, we investigated the effects of hinokitiol, a small-molecule natural compound,
against neuronal ferroptosis after traumatic brain injury (TBI). A controlled cortical impact …

Inflammatory neuropsychiatric disorders and COVID-19 neuroinflammation

SW Tang, D Helmeste, B Leonard - Acta Neuropsychiatrica, 2021 - cambridge.org
Neuropsychiatric sequalae to coronavirus disease 2019 (COVID-19) infection are beginning
to emerge, like previous Spanish influenza and severe acute respiratory syndrome …

Oxytocin and microglia in the development of social behaviour

A Gonzalez, EAD Hammock - … Transactions of the …, 2022 - royalsocietypublishing.org
Oxytocin is a well-established regulator of social behaviour. Microglia, the resident immune
cells of the central nervous system, regulate brain development and maintenance in health …