Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Multisteric TRPV1 nocisensor: a target for analgesics
J Szolcsányi, Z Sándor - Trends in pharmacological sciences, 2012 - cell.com
Cloning of the transient receptor potential vanilloid type 1 (TRPV1), the heat-gated cation
channel/capsaicin receptor expressed by sensory neurons, has opened the door for …
channel/capsaicin receptor expressed by sensory neurons, has opened the door for …
[BOEK][B] Mammalian transient receptor potential (TRP) cation channels
B Nilius, V Flockerzi - 2014 - Springer
When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …
Capsaicin interaction with TRPV1 channels in a lipid bilayer: molecular dynamics simulation
Transient receptor potential vanilloid subtype 1 (TRPV1) is a heat-sensitive ion channel also
involved in pain sensation, and is the receptor for capsaicin, the active ingredient of hot chili …
involved in pain sensation, and is the receptor for capsaicin, the active ingredient of hot chili …
Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel
The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1),
has been identified as a polymodal transducer molecule on a sub-set of primary sensory …
has been identified as a polymodal transducer molecule on a sub-set of primary sensory …
Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel-an overview of the current mutational data
This review aims to create an overview of the currently available results of site-directed
mutagenesis studies on transient receptor potential vanilloid type 1 (TRPV1) receptor …
mutagenesis studies on transient receptor potential vanilloid type 1 (TRPV1) receptor …
Insights from molecular dynamics simulations of TRPV1 channel modulators in pain
TRPV1 is a nonselective cation channel vital for detecting noxious stimuli (heat, acid,
capsaicin). Its role in pain makes it a potential drug target for chronic pain management …
capsaicin). Its role in pain makes it a potential drug target for chronic pain management …
A new era for the design of TRPV1 antagonists and agonists with the use of structural information and molecular docking of capsaicin-like compounds
J Caballero - Journal of enzyme inhibition and medicinal chemistry, 2022 - Taylor & Francis
The design of TRPV1 antagonists and agonists has reached a new era since TRPV1
structures at near-atomic resolution are available. Today, the ligand-binding forms of several …
structures at near-atomic resolution are available. Today, the ligand-binding forms of several …
TRPV1: Receptor structure, activation, modulation and role in neuro-immune interactions and pain
In the 1990s, the identification of a non-selective ion channel, especially responsive to
capsaicin, revolutionized the studies of somatosensation and pain that were to follow. The …
capsaicin, revolutionized the studies of somatosensation and pain that were to follow. The …
Transient receptor potential vanilloid type 1 antagonists: a patent review (2011–2014)
Introduction: Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation
channel that can be activated by noxious heat, low pH and vanilloid compounds such as …
channel that can be activated by noxious heat, low pH and vanilloid compounds such as …