Neurotrophin secretion: current facts and future prospects
The proteins of the mammalian neurotrophin family (nerve growth factor (NGF), brain-
derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5)) …
derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5)) …
The spiral ganglion: connecting the peripheral and central auditory systems
In mammals, the initial bridge between the physical world of sound and perception of that
sound is established by neurons of the spiral ganglion. The cell bodies of these neurons …
sound is established by neurons of the spiral ganglion. The cell bodies of these neurons …
[HTML][HTML] Essential role for TrkB receptors in hippocampus-mediated learning
Brain-derived neurotrophic factor (BDNF) and its receptor TrkB regulate both short-term
synaptic functions and long-term potentiation (LTP) of brain synapses, raising the possibility …
synaptic functions and long-term potentiation (LTP) of brain synapses, raising the possibility …
Hair cell mechanotransduction regulates spontaneous activity and spiral ganglion subtype specification in the auditory system
Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to
the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that …
the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that …
Single-cell RNA-sequencing analysis of the develo** mouse inner ear identifies molecular logic of auditory neuron diversification
Different types of spiral ganglion neurons (SGNs) are essential for auditory perception by
transmitting complex auditory information from hair cells (HCs) to the brain. Here, we use …
transmitting complex auditory information from hair cells (HCs) to the brain. Here, we use …
Development in the mammalian auditory system depends on transcription factors
We review the molecular basis of several transcription factors (Eya1, Sox2), including the
three related genes coding basic helix–loop–helix (bHLH; see abbreviations) proteins …
three related genes coding basic helix–loop–helix (bHLH; see abbreviations) proteins …
Spatial sha** of cochlear innervation by temporally regulated neurotrophin expression
I Fariñas, KR Jones, L Tessarollo… - Journal of …, 2001 - Soc Neuroscience
Previous work suggested qualitatively different effects of neurotrophin 3 (NT-3) in cochlear
innervation patterning in different null mutants. We now show that all NT-3 null mutants have …
innervation patterning in different null mutants. We now show that all NT-3 null mutants have …
The role of BDNF as a biomarker in cognitive and sensory neurodegeneration
A Pisani, F Paciello, V Del Vecchio, R Malesci… - Journal of Personalized …, 2023 - mdpi.com
Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous
system and in sensory structures including olfactory and auditory systems. Many studies …
system and in sensory structures including olfactory and auditory systems. Many studies …
Is type 2 diabetes mellitus associated with alterations in hearing? A systematic review and meta‐analysis
OV Akinpelu, M Mujica‐Mota, SJ Daniel - The Laryngoscope, 2014 - Wiley Online Library
Objectives/Hypothesis The aim of this study was to systematically and quantitatively review
the available evidence on the effects of type 2 diabetes mellitus on hearing function. Data …
the available evidence on the effects of type 2 diabetes mellitus on hearing function. Data …
Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems
M Liu, FA Pereira, SD Price, M Chu… - Genes & …, 2000 - genesdev.cshlp.org
BETA2/NeuroD1 is a bHLH transcription factor that is expressed during development in the
mammalian pancreas and in many locations in the central and peripheral nervous systems …
mammalian pancreas and in many locations in the central and peripheral nervous systems …